DegronMD - O14498(ISLR)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G289V	TCGA-B9-A5W9	KIRP	TCGA	LPGTPVAS	DEG_SCF_FBW7_1	292:299	Mutation rewiring degron network	0.25
p.G289V	DO44511	KIRP	ICGC	LPGTPVAS	DEG_SCF_FBW7_1	292:299	Mutation rewiring degron network	0.25
p.R290C	TCGA-BR-A4QL	STAD	TCGA	LPGTPVAS	DEG_SCF_FBW7_1	292:299	Mutation rewiring degron network	0.2778
p.R290C	DO38723	STAD	ICGC	LPGTPVAS	DEG_SCF_FBW7_1	292:299	Mutation rewiring degron network	0.2778
p.R290C	DO41199	UCEC	ICGC	LPGTPVAS	DEG_SCF_FBW7_1	292:299	Mutation rewiring degron network	0.2778
p.R290C	DO229547	UTCA	ICGC	LPGTPVAS	DEG_SCF_FBW7_1	292:299	Mutation rewiring degron network	0.2778
p.V285A	TCGA-C8-A130	BRCA	TCGA	LPGTPVAS	DEG_SCF_FBW7_1	292:299	Mutation rewiring degron network	0.1389
p.V285A	DO3804	BRCA	ICGC	LPGTPVAS	DEG_SCF_FBW7_1	292:299	Mutation rewiring degron network	0.1389
p.P296L	TCGA-DK-A1AC	BLCA	TCGA	LPGTPVAS	DEG_SCF_FBW7_1	292:299	Mutation altering degron motif	0.7582
p.P296L	DO514	BLCA	ICGC	LPGTPVAS	DEG_SCF_FBW7_1	292:299	Mutation altering degron motif	0.7582
p.A306D	TCGA-IG-A51D	ESCA	TCGA	LPGTPVAS	DEG_SCF_FBW7_1	292:299	Mutation rewiring degron network	0.1389
p.N284S	DO233687	GACA	ICGC	LPGTPVAS	DEG_SCF_FBW7_1	292:299	Mutation rewiring degron network	0.1111
p.P296S	DO222494	MELA	ICGC	LPGTPVAS	DEG_SCF_FBW7_1	292:299	Mutation altering degron motif	0.6752
p.S282T	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	LPGTPVAS	DEG_SCF_FBW7_1	292:299	Mutation rewiring degron network	0.0556
p.S282T	ACH-000747	Lung Cancer	CCLE	LPGTPVAS	DEG_SCF_FBW7_1	292:299	Mutation rewiring degron network	0.0556
p.S282T	NCI-H1703	lung	COSMIC	LPGTPVAS	DEG_SCF_FBW7_1	292:299	Mutation rewiring degron network	0.0556

Kaplan plot for ISLR in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ISLR

UniProt ID: O14498

Entrez ID: 3671

Protein name: Immunoglobulin superfamily containing leucine-rich repeat protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ISLR in