DegronMD

Uniprot ID: O14498

Source protein: Immunoglobulin superfamily containing leucine-rich repeat protein

Source gene: ISLR

Class: DEG_SCF_FBW7_1

Location: 292:299

E3 ligase: FBXW7

DEGRON score: 0.941

ASA_SCORE: 58.3125

COIL: 0.7836

CONS_SCORE: 0.4324

DSS_SCORE: 0.5365

HELIX: 0.027

FCONS_SCORE: 0.5595

RIG_SCORE: 0.6915

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G289V	TCGA-B9-A5W9	KIRP	TCGA	LPGTPVAS	DEG_SCF_FBW7_1	0.25
p.G289V	DO44511	KIRP	ICGC	LPGTPVAS	DEG_SCF_FBW7_1	0.25
p.R290C	TCGA-BR-A4QL	STAD	TCGA	LPGTPVAS	DEG_SCF_FBW7_1	0.2778
p.R290C	DO38723	STAD	ICGC	LPGTPVAS	DEG_SCF_FBW7_1	0.2778
p.R290C	DO41199	UCEC	ICGC	LPGTPVAS	DEG_SCF_FBW7_1	0.2778
p.R290C	DO229547	UTCA	ICGC	LPGTPVAS	DEG_SCF_FBW7_1	0.2778
p.V285A	TCGA-C8-A130	BRCA	TCGA	LPGTPVAS	DEG_SCF_FBW7_1	0.1389
p.V285A	DO3804	BRCA	ICGC	LPGTPVAS	DEG_SCF_FBW7_1	0.1389
p.P296L	TCGA-DK-A1AC	BLCA	TCGA	LPGTPVAS	DEG_SCF_FBW7_1	0.7582
p.P296L	DO514	BLCA	ICGC	LPGTPVAS	DEG_SCF_FBW7_1	0.7582
p.A306D	TCGA-IG-A51D	ESCA	TCGA	LPGTPVAS	DEG_SCF_FBW7_1	0.1389
p.N284S	DO233687	GACA	ICGC	LPGTPVAS	DEG_SCF_FBW7_1	0.1111
p.P296S	DO222494	MELA	ICGC	LPGTPVAS	DEG_SCF_FBW7_1	0.6752
p.S282T	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	LPGTPVAS	DEG_SCF_FBW7_1	0.0556
p.S282T	ACH-000747	Lung Cancer	CCLE	LPGTPVAS	DEG_SCF_FBW7_1	0.0556
p.S282T	NCI-H1703	lung	COSMIC	LPGTPVAS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14498	Immunoglobulin superfamily containing leucine-rich repeat protein	DEG_SCF_FBW7_1	292:299	LPGTPVAS	FBXW7	0.941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons