DegronMD - O14562(UBFD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V71I	TCGA-05-4433	LUAD	TCGA	SVSNGE	DEG_Kelch_Keap1_1	70:75	Mutation altering degron motif	0.5965
p.V71I	DO25857	LUAD	ICGC	SVSNGE	DEG_Kelch_Keap1_1	70:75	Mutation altering degron motif	0.5965
p.D64N	TCGA-BR-8680	STAD	TCGA	SVSNGE	DEG_Kelch_Keap1_1	70:75	Mutation rewiring degron network	0.1667
p.D64N	DO47769	STAD	ICGC	SVSNGE	DEG_Kelch_Keap1_1	70:75	Mutation rewiring degron network	0.1667
p.Q60K	TCGA-EE-A3AG	SKCM	TCGA	SVSNGE	DEG_Kelch_Keap1_1	70:75	Mutation rewiring degron network	0.0556
p.Q60K	DO37471	SKCM	ICGC	SVSNGE	DEG_Kelch_Keap1_1	70:75	Mutation rewiring degron network	0.0556
p.R77G	DO234424	ESAD	ICGC	SVSNGE	DEG_Kelch_Keap1_1	70:75	Mutation rewiring degron network	0.2778
p.R77Q	DO233828	GACA	ICGC	SVSNGE	DEG_Kelch_Keap1_1	70:75	Mutation rewiring degron network	0.2778
p.G80C	DO229031	LICA	ICGC	SVSNGE	DEG_Kelch_Keap1_1	70:75	Mutation rewiring degron network	0.1944
p.A77S	DO232053	ORCA	ICGC	SVSNGE	DEG_Kelch_Keap1_1	70:75	Mutation rewiring degron network	0.2778
p.V64A	DO41999	UCEC	ICGC	SVSNGE	DEG_Kelch_Keap1_1	70:75	Mutation rewiring degron network	0.1667
p.R74K	DO41871	UCEC	ICGC	SVSNGE	DEG_Kelch_Keap1_1	70:75	Mutation altering degron motif	0.7237
p.V71G	SIDM01188	Pancreatic Carcinoma	GDSC	SVSNGE	DEG_Kelch_Keap1_1	70:75	Mutation altering degron motif	0.6421
p.A66G	SIDM00730	Small Cell Lung Carcinoma	GDSC	SVSNGE	DEG_Kelch_Keap1_1	70:75	Mutation rewiring degron network	0.2222
p.A66G	ACH-000610	Lung Cancer	CCLE	SVSNGE	DEG_Kelch_Keap1_1	70:75	Mutation rewiring degron network	0.2222
p.A66G	NCI-H2227	lung	COSMIC	SVSNGE	DEG_Kelch_Keap1_1	70:75	Mutation rewiring degron network	0.2222

Kaplan plot for UBFD1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UBFD1

UniProt ID: O14562

Entrez ID: 56061

Protein name: Ubiquitin domain-containing protein UBFD1 (Ubiquitin-binding protein homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UBFD1 in