DegronMD

Uniprot ID: O14562

Source protein: Ubiquitin domain-containing protein UBFD1

Source gene: UBFD1

Class: DEG_Kelch_Keap1_1

Location: 70:75

E3 ligase: KEAP1

DEGRON score: 0.9935

ASA_SCORE: 87.5333

COIL: 0.8242

CONS_SCORE: 0.4642

DSS_SCORE: 0.6964

HELIX: 0.1338

FCONS_SCORE: 1.1201

RIG_SCORE: 0.6143

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V71I	TCGA-05-4433	LUAD	TCGA	SVSNGE	DEG_Kelch_Keap1_1	0.5965
p.V71I	DO25857	LUAD	ICGC	SVSNGE	DEG_Kelch_Keap1_1	0.5965
p.D64N	TCGA-BR-8680	STAD	TCGA	SVSNGE	DEG_Kelch_Keap1_1	0.1667
p.D64N	DO47769	STAD	ICGC	SVSNGE	DEG_Kelch_Keap1_1	0.1667
p.Q60K	TCGA-EE-A3AG	SKCM	TCGA	SVSNGE	DEG_Kelch_Keap1_1	0.0556
p.Q60K	DO37471	SKCM	ICGC	SVSNGE	DEG_Kelch_Keap1_1	0.0556
p.R77G	DO234424	ESAD	ICGC	SVSNGE	DEG_Kelch_Keap1_1	0.2778
p.R77Q	DO233828	GACA	ICGC	SVSNGE	DEG_Kelch_Keap1_1	0.2778
p.G80C	DO229031	LICA	ICGC	SVSNGE	DEG_Kelch_Keap1_1	0.1944
p.A77S	DO232053	ORCA	ICGC	SVSNGE	DEG_Kelch_Keap1_1	0.2778
p.V64A	DO41999	UCEC	ICGC	SVSNGE	DEG_Kelch_Keap1_1	0.1667
p.R74K	DO41871	UCEC	ICGC	SVSNGE	DEG_Kelch_Keap1_1	0.7237
p.V71G	SIDM01188	Pancreatic Carcinoma	GDSC	SVSNGE	DEG_Kelch_Keap1_1	0.6421
p.A66G	SIDM00730	Small Cell Lung Carcinoma	GDSC	SVSNGE	DEG_Kelch_Keap1_1	0.2222
p.A66G	ACH-000610	Lung Cancer	CCLE	SVSNGE	DEG_Kelch_Keap1_1	0.2222
p.A66G	NCI-H2227	lung	COSMIC	SVSNGE	DEG_Kelch_Keap1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14562	Ubiquitin domain-containing protein UBFD1	DEG_Kelch_Keap1_1	70:75	SVSNGE	KEAP1	0.9935	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons