DegronMD - O14579(COPE)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K288N	TCGA-EE-A183	SKCM	TCGA	AKEND	DEG_APCC_KENBOX_2	292:296	Mutation blocking ubiquitination signal	0.6667
p.L302P	TCGA-LN-A4A3	ESCA	TCGA	AKEND	DEG_APCC_KENBOX_2	292:296	Mutation rewiring degron network	0.1667
p.Q299L	DO45475	LUSC	ICGC	AKEND	DEG_APCC_KENBOX_2	292:296	Mutation rewiring degron network	0.25
p.L302V	ACH-000710	Lung Cancer	CCLE	AKEND	DEG_APCC_KENBOX_2	292:296	Mutation rewiring degron network	0.1667
p.P285L	ACH-000835	Sarcoma	CCLE	AKEND	DEG_APCC_KENBOX_2	292:296	Mutation rewiring degron network	0.1389
p.P285L	GCT	soft tissue	COSMIC	AKEND	DEG_APCC_KENBOX_2	292:296	Mutation rewiring degron network	0.1389
p.D298V	ACH-001131	Skin Cancer	CCLE	AKEND	DEG_APCC_KENBOX_2	292:296	Mutation rewiring degron network	0.2778
p.D298V	ACH-001958	lung	CCLE	AKEND	DEG_APCC_KENBOX_2	292:296	Mutation rewiring degron network	0.2778
p.D298V	MS-1	lung	COSMIC	AKEND	DEG_APCC_KENBOX_2	292:296	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons