DegronMD

Uniprot ID: O14579

Source protein: Coatomer subunit epsilon

Source gene: COPE

Class: DEG_APCC_KENBOX_2

Location: 292:296

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5608

ASA_SCORE: 62.54

COIL: 0.0278

CONS_SCORE: 0.4259

DSS_SCORE: 0.2785

HELIX: 0.9716

FCONS_SCORE: 1.0846

RIG_SCORE: 0.7821

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K288N	TCGA-EE-A183	SKCM	TCGA	AKEND	DEG_APCC_KENBOX_2	0.6667
p.L302P	TCGA-LN-A4A3	ESCA	TCGA	AKEND	DEG_APCC_KENBOX_2	0.1667
p.Q299L	DO45475	LUSC	ICGC	AKEND	DEG_APCC_KENBOX_2	0.25
p.L302V	ACH-000710	Lung Cancer	CCLE	AKEND	DEG_APCC_KENBOX_2	0.1667
p.P285L	ACH-000835	Sarcoma	CCLE	AKEND	DEG_APCC_KENBOX_2	0.1389
p.P285L	GCT	soft_tissue	COSMIC	AKEND	DEG_APCC_KENBOX_2	0.1389
p.D298V	ACH-001131	Skin Cancer	CCLE	AKEND	DEG_APCC_KENBOX_2	0.2778
p.D298V	ACH-001958	lung	CCLE	AKEND	DEG_APCC_KENBOX_2	0.2778
p.D298V	MS-1	lung	COSMIC	AKEND	DEG_APCC_KENBOX_2	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons