DegronMD

Uniprot ID: P49756

Source protein: RNA-binding protein 25

Source gene: RBM25

Class: DEG_APCC_KENBOX_2

Location: 76:80

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7457

ASA_SCORE: 101.1

COIL: 0.8728

CONS_SCORE: 0.2265

DSS_SCORE: 0.5962

HELIX: 0.086

FCONS_SCORE: 0.6626

RIG_SCORE: 0.6935

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N82Y	TCGA-06-1805	GBM	TCGA	AKEND	DEG_APCC_KENBOX_2	0.2778
p.N82Y	DO11567	GBM	ICGC	AKEND	DEG_APCC_KENBOX_2	0.2778
p.N82S	TCGA-06-1805	GBM	TCGA	AKEND	DEG_APCC_KENBOX_2	0.2778
p.N82S	DO11567	GBM	ICGC	AKEND	DEG_APCC_KENBOX_2	0.2778
p.K69N	TCGA-2W-A8YY	CESC	TCGA	AKEND	DEG_APCC_KENBOX_2	0.25
p.K69N	DO223732	CESC	ICGC	AKEND	DEG_APCC_KENBOX_2	0.25
p.A76T	TCGA-A5-A0G1	UCEC	TCGA	AKEND	DEG_APCC_KENBOX_2	0.6028
p.A76T	DO42472	UCEC	ICGC	AKEND	DEG_APCC_KENBOX_2	0.6028
p.G66S	TCGA-AP-A1DV	UCEC	TCGA	AKEND	DEG_APCC_KENBOX_2	0.0556
p.G66S	DO43186	UCEC	ICGC	AKEND	DEG_APCC_KENBOX_2	0.0556
p.A67T	TCGA-B5-A1MR	UCEC	TCGA	AKEND	DEG_APCC_KENBOX_2	0.0833
p.A67T	TCGA-F1-6177	STAD	TCGA	AKEND	DEG_APCC_KENBOX_2	0.0833
p.A67T	DO38727	STAD	ICGC	AKEND	DEG_APCC_KENBOX_2	0.0833
p.A67T	DO41758	UCEC	ICGC	AKEND	DEG_APCC_KENBOX_2	0.0833
p.K69Q	TCGA-CD-8529	STAD	TCGA	AKEND	DEG_APCC_KENBOX_2	0.25
p.K69Q	DO47753	STAD	ICGC	AKEND	DEG_APCC_KENBOX_2	0.25
p.T87A	TCGA-CG-5721	STAD	TCGA	AKEND	DEG_APCC_KENBOX_2	0.1389
p.T87A	DO38192	STAD	ICGC	AKEND	DEG_APCC_KENBOX_2	0.1389
p.N82T	TCGA-EO-A3B0	UCEC	TCGA	AKEND	DEG_APCC_KENBOX_2	0.2778
p.N82T	DO219773	UCEC	ICGC	AKEND	DEG_APCC_KENBOX_2	0.2778
p.P72S	DO230337	COCA	ICGC	AKEND	DEG_APCC_KENBOX_2	0.2222
p.A67S	DO229015	LICA	ICGC	AKEND	DEG_APCC_KENBOX_2	0.0833
p.T87N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	AKEND	DEG_APCC_KENBOX_2	0.1389
p.T87N	ACH-002256	Leukemia	CCLE	AKEND	DEG_APCC_KENBOX_2	0.1389
p.T87N	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	AKEND	DEG_APCC_KENBOX_2	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons