DegronMD - P49756(RBM25)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N82Y	TCGA-06-1805	GBM	TCGA	AKEND	DEG_APCC_KENBOX_2	76:80	Mutation rewiring degron network	0.2778
p.N82Y	DO11567	GBM	ICGC	AKEND	DEG_APCC_KENBOX_2	76:80	Mutation rewiring degron network	0.2778
p.N82S	TCGA-06-1805	GBM	TCGA	AKEND	DEG_APCC_KENBOX_2	76:80	Mutation rewiring degron network	0.2778
p.N82S	DO11567	GBM	ICGC	AKEND	DEG_APCC_KENBOX_2	76:80	Mutation rewiring degron network	0.2778
p.K69N	TCGA-2W-A8YY	CESC	TCGA	AKEND	DEG_APCC_KENBOX_2	76:80	Mutation substituting flanking lysine	0.25
p.K69N	DO223732	CESC	ICGC	AKEND	DEG_APCC_KENBOX_2	76:80	Mutation substituting flanking lysine	0.25
p.A76T	TCGA-A5-A0G1	UCEC	TCGA	AKEND	DEG_APCC_KENBOX_2	76:80	Mutation altering degron motif	0.6028
p.A76T	DO42472	UCEC	ICGC	AKEND	DEG_APCC_KENBOX_2	76:80	Mutation altering degron motif	0.6028
p.G66S	TCGA-AP-A1DV	UCEC	TCGA	AKEND	DEG_APCC_KENBOX_2	76:80	Mutation rewiring degron network	0.0556
p.G66S	DO43186	UCEC	ICGC	AKEND	DEG_APCC_KENBOX_2	76:80	Mutation rewiring degron network	0.0556
p.A67T	TCGA-B5-A1MR	UCEC	TCGA	AKEND	DEG_APCC_KENBOX_2	76:80	Mutation rewiring degron network	0.0833
p.A67T	TCGA-F1-6177	STAD	TCGA	AKEND	DEG_APCC_KENBOX_2	76:80	Mutation rewiring degron network	0.0833
p.A67T	DO38727	STAD	ICGC	AKEND	DEG_APCC_KENBOX_2	76:80	Mutation rewiring degron network	0.0833
p.A67T	DO41758	UCEC	ICGC	AKEND	DEG_APCC_KENBOX_2	76:80	Mutation rewiring degron network	0.0833
p.K69Q	TCGA-CD-8529	STAD	TCGA	AKEND	DEG_APCC_KENBOX_2	76:80	Mutation substituting flanking lysine	0.25
p.K69Q	DO47753	STAD	ICGC	AKEND	DEG_APCC_KENBOX_2	76:80	Mutation substituting flanking lysine	0.25
p.T87A	TCGA-CG-5721	STAD	TCGA	AKEND	DEG_APCC_KENBOX_2	76:80	Mutation rewiring degron network	0.1389
p.T87A	DO38192	STAD	ICGC	AKEND	DEG_APCC_KENBOX_2	76:80	Mutation rewiring degron network	0.1389
p.N82T	TCGA-EO-A3B0	UCEC	TCGA	AKEND	DEG_APCC_KENBOX_2	76:80	Mutation rewiring degron network	0.2778
p.N82T	DO219773	UCEC	ICGC	AKEND	DEG_APCC_KENBOX_2	76:80	Mutation rewiring degron network	0.2778
p.P72S	DO230337	COCA	ICGC	AKEND	DEG_APCC_KENBOX_2	76:80	Mutation rewiring degron network	0.2222
p.A67S	DO229015	LICA	ICGC	AKEND	DEG_APCC_KENBOX_2	76:80	Mutation rewiring degron network	0.0833
p.T87N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	AKEND	DEG_APCC_KENBOX_2	76:80	Mutation rewiring degron network	0.1389
p.T87N	ACH-002256	Leukemia	CCLE	AKEND	DEG_APCC_KENBOX_2	76:80	Mutation rewiring degron network	0.1389
p.T87N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	AKEND	DEG_APCC_KENBOX_2	76:80	Mutation rewiring degron network	0.1389

Kaplan plot for RBM25 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RBM25

UniProt ID: P49756

Entrez ID: 58517

Protein name: RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RBM25 in