DegronMD - O14613(CDC42EP2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q139H	TCGA-DU-6392	LGG	TCGA	LETPQPS	DEG_SCF_FBW7_1	135:141	Mutation altering degron motif	0.647
p.Q139H	DO22237	LGG	ICGC	LETPQPS	DEG_SCF_FBW7_1	135:141	Mutation altering degron motif	0.647
p.S141F	TCGA-EB-A41A	SKCM	TCGA	LETPQPS	DEG_SCF_FBW7_1	135:141	Mutation altering degron motif	0.9093
p.S141F	DO37429	SKCM	ICGC	LETPQPS	DEG_SCF_FBW7_1	135:141	Mutation altering degron motif	0.9093
p.G146V	TCGA-ET-A39R	THCA	TCGA	LETPQPS	DEG_SCF_FBW7_1	135:141	Mutation rewiring degron network	0.1944
p.G146V	DO39552	THCA	ICGC	LETPQPS	DEG_SCF_FBW7_1	135:141	Mutation rewiring degron network	0.1944
p.Q143H	DO228952	LICA	ICGC	LETPQPS	DEG_SCF_FBW7_1	135:141	Mutation rewiring degron network	0.2778
p.R132C	SIDM00875	Breast Carcinoma	GDSC	LETPQPS	DEG_SCF_FBW7_1	135:141	Mutation rewiring degron network	0.25
p.R132C	ACH-000624	Breast Cancer	CCLE	LETPQPS	DEG_SCF_FBW7_1	135:141	Mutation rewiring degron network	0.25
p.R132C	HCC1806	breast	COSMIC	LETPQPS	DEG_SCF_FBW7_1	135:141	Mutation rewiring degron network	0.25

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons