DegronMD

Uniprot ID: O14613

Source protein: Cdc42 effector protein 2

Source gene: CDC42EP2

Class: DEG_SCF_FBW7_1

Location: 135:141

E3 ligase: FBXW7

DEGRON score: 0.8476

ASA_SCORE: 84.6857

COIL: 0.9404

CONS_SCORE: 0.7066

DSS_SCORE: 0.8313

HELIX: 0.0287

FCONS_SCORE: 0.9152

RIG_SCORE: 0.6055

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q139H	TCGA-DU-6392	LGG	TCGA	LETPQPS	DEG_SCF_FBW7_1	0.647
p.Q139H	DO22237	LGG	ICGC	LETPQPS	DEG_SCF_FBW7_1	0.647
p.S141F	TCGA-EB-A41A	SKCM	TCGA	LETPQPS	DEG_SCF_FBW7_1	0.9093
p.S141F	DO37429	SKCM	ICGC	LETPQPS	DEG_SCF_FBW7_1	0.9093
p.G146V	TCGA-ET-A39R	THCA	TCGA	LETPQPS	DEG_SCF_FBW7_1	0.1944
p.G146V	DO39552	THCA	ICGC	LETPQPS	DEG_SCF_FBW7_1	0.1944
p.Q143H	DO228952	LICA	ICGC	LETPQPS	DEG_SCF_FBW7_1	0.2778
p.R132C	SIDM00875	Breast Carcinoma	GDSC	LETPQPS	DEG_SCF_FBW7_1	0.25
p.R132C	ACH-000624	Breast Cancer	CCLE	LETPQPS	DEG_SCF_FBW7_1	0.25
p.R132C	HCC1806	breast	COSMIC	LETPQPS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14613	Cdc42 effector protein 2	DEG_SCF_FBW7_1	135:141	LETPQPS	FBXW7	0.8476	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons