DegronMD - O14618(CCS)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A179T	TCGA-21-1080	LUSC	TCGA	HRGDLGNVR	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.1389
p.A179T	DO26502	LUSC	ICGC	HRGDLGNVR	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.1389
p.D174H	TCGA-33-A4WN	LUSC	TCGA	HRGDLGNVR	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.2778
p.D174H	DO219121	LUSC	ICGC	HRGDLGNVR	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.2778
p.H164Q	TCGA-98-A53A	LUSC	TCGA	HRGDLGNVR	DEG_APCC_DBOX_1	164:172	Mutation altering degron motif	0.647
p.H164Q	DO219178	LUSC	ICGC	HRGDLGNVR	DEG_APCC_DBOX_1	164:172	Mutation altering degron motif	0.647
p.H155N	TCGA-A3-A6NL	KIRC	TCGA	HRGDLGNVR	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.0833
p.H155N	DO50458	KIRC	ICGC	HRGDLGNVR	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.0833
p.R182K	TCGA-D3-A1QB	SKCM	TCGA	HRGDLGNVR	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.0556
p.R182K	DO47573	SKCM	ICGC	HRGDLGNVR	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.0556
p.S161F	TCGA-D3-A8GB	SKCM	TCGA	HRGDLGNVR	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.25
p.S161F	DO50280	SKCM	ICGC	HRGDLGNVR	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.25
p.G157C	DO228948	LICA	ICGC	HRGDLGNVR	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.1389
p.R178L	DO229015	LICA	ICGC	HRGDLGNVR	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.1667
p.G169C	DO229025	LICA	ICGC	HRGDLGNVR	DEG_APCC_DBOX_1	164:172	Mutation altering degron motif	0.6489
p.A173T	DO46542	OV	ICGC	HRGDLGNVR	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.3056
p.R178C	SIDM01943	Colorectal Carcinoma	GDSC	HRGDLGNVR	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.1667
p.R165H	SIDM00113	Kidney Carcinoma	GDSC	HRGDLGNVR	DEG_APCC_DBOX_1	164:172	Mutation altering degron motif	0.8244
p.R165H	ACH-001208	Kidney Cancer	CCLE	HRGDLGNVR	DEG_APCC_DBOX_1	164:172	Mutation altering degron motif	0.8244
p.R165H	TK10	kidney	COSMIC	HRGDLGNVR	DEG_APCC_DBOX_1	164:172	Mutation altering degron motif	0.8244
p.H155R	SIDM01154	T-Lymphoblastic Leukemia	GDSC	HRGDLGNVR	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.0833
p.H155R	ACH-000953	Leukemia	CCLE	HRGDLGNVR	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.0833
p.H155R	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	HRGDLGNVR	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.0833
p.R165C	SIDM00767	Small Cell Lung Carcinoma	GDSC	HRGDLGNVR	DEG_APCC_DBOX_1	164:172	Mutation altering degron motif	0.8301
p.R165C	ACH-001136	Lung Cancer	CCLE	HRGDLGNVR	DEG_APCC_DBOX_1	164:172	Mutation altering degron motif	0.8301
p.R165C	NCI-H187	lung	COSMIC	HRGDLGNVR	DEG_APCC_DBOX_1	164:172	Mutation altering degron motif	0.8301
p.R163W	SIDM00875	Breast Carcinoma	GDSC	HRGDLGNVR	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.3056
p.Q159H	SIDM01609	Endometrial Carcinoma	GDSC	HRGDLGNVR	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.1944
p.Q159H	ACH-000972	Endometrial/Uterine Cancer	CCLE	HRGDLGNVR	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.1944

Kaplan plot for CCS in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCS

UniProt ID: O14618

Entrez ID: 9973

Protein name: Copper chaperone for superoxide dismutase (Superoxide dismutase copper chaperone)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCS in