DegronMD

Uniprot ID: O14618

Source protein: Copper chaperone for superoxide dismutase

Source gene: CCS

Class: DEG_APCC_DBOX_1

Location: 164:172

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8996

ASA_SCORE: 49.4222

COIL: 0.4576

CONS_SCORE: 0.4983

DSS_SCORE: 0.5728

HELIX: 0.0566

FCONS_SCORE: 1.246

RIG_SCORE: 0.6639

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A179T	TCGA-21-1080	LUSC	TCGA	HRGDLGNVR	DEG_APCC_DBOX_1	0.1389
p.A179T	DO26502	LUSC	ICGC	HRGDLGNVR	DEG_APCC_DBOX_1	0.1389
p.D174H	TCGA-33-A4WN	LUSC	TCGA	HRGDLGNVR	DEG_APCC_DBOX_1	0.2778
p.D174H	DO219121	LUSC	ICGC	HRGDLGNVR	DEG_APCC_DBOX_1	0.2778
p.H164Q	TCGA-98-A53A	LUSC	TCGA	HRGDLGNVR	DEG_APCC_DBOX_1	0.647
p.H164Q	DO219178	LUSC	ICGC	HRGDLGNVR	DEG_APCC_DBOX_1	0.647
p.H155N	TCGA-A3-A6NL	KIRC	TCGA	HRGDLGNVR	DEG_APCC_DBOX_1	0.0833
p.H155N	DO50458	KIRC	ICGC	HRGDLGNVR	DEG_APCC_DBOX_1	0.0833
p.R182K	TCGA-D3-A1QB	SKCM	TCGA	HRGDLGNVR	DEG_APCC_DBOX_1	0.0556
p.R182K	DO47573	SKCM	ICGC	HRGDLGNVR	DEG_APCC_DBOX_1	0.0556
p.S161F	TCGA-D3-A8GB	SKCM	TCGA	HRGDLGNVR	DEG_APCC_DBOX_1	0.25
p.S161F	DO50280	SKCM	ICGC	HRGDLGNVR	DEG_APCC_DBOX_1	0.25
p.G157C	DO228948	LICA	ICGC	HRGDLGNVR	DEG_APCC_DBOX_1	0.1389
p.R178L	DO229015	LICA	ICGC	HRGDLGNVR	DEG_APCC_DBOX_1	0.1667
p.G169C	DO229025	LICA	ICGC	HRGDLGNVR	DEG_APCC_DBOX_1	0.6489
p.A173T	DO46542	OV	ICGC	HRGDLGNVR	DEG_APCC_DBOX_1	0.3056
p.R178C	SIDM01943	Colorectal Carcinoma	GDSC	HRGDLGNVR	DEG_APCC_DBOX_1	0.1667
p.R165H	SIDM00113	Kidney Carcinoma	GDSC	HRGDLGNVR	DEG_APCC_DBOX_1	0.8244
p.R165H	ACH-001208	Kidney Cancer	CCLE	HRGDLGNVR	DEG_APCC_DBOX_1	0.8244
p.R165H	TK10	kidney	COSMIC	HRGDLGNVR	DEG_APCC_DBOX_1	0.8244
p.H155R	SIDM01154	T-Lymphoblastic Leukemia	GDSC	HRGDLGNVR	DEG_APCC_DBOX_1	0.0833
p.H155R	ACH-000953	Leukemia	CCLE	HRGDLGNVR	DEG_APCC_DBOX_1	0.0833
p.H155R	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	HRGDLGNVR	DEG_APCC_DBOX_1	0.0833
p.R165C	SIDM00767	Small Cell Lung Carcinoma	GDSC	HRGDLGNVR	DEG_APCC_DBOX_1	0.8301
p.R165C	ACH-001136	Lung Cancer	CCLE	HRGDLGNVR	DEG_APCC_DBOX_1	0.8301
p.R165C	NCI-H187	lung	COSMIC	HRGDLGNVR	DEG_APCC_DBOX_1	0.8301
p.R163W	SIDM00875	Breast Carcinoma	GDSC	HRGDLGNVR	DEG_APCC_DBOX_1	0.3056
p.Q159H	SIDM01609	Endometrial Carcinoma	GDSC	HRGDLGNVR	DEG_APCC_DBOX_1	0.1944
p.Q159H	ACH-000972	Endometrial/Uterine Cancer	CCLE	HRGDLGNVR	DEG_APCC_DBOX_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: HRGDLGNVR

Degron related mutations and impact score

Drug responses associated with CCS mutations

All proteins holding degron of HRGDLGNVR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14618	Copper chaperone for superoxide dismutase	DEG_APCC_DBOX_1	164:172	HRGDLGNVR	APC,CDC20,FZR1	0.8996	More...