DegronMD - O14730(RIOK3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V132I	TCGA-49-6743	LUAD	TCGA	VHPYED	LIG_APCC_ABBA_1	119:124	Mutation rewiring degron network	0.1111
p.V132I	DO26092	LUAD	ICGC	VHPYED	LIG_APCC_ABBA_1	119:124	Mutation rewiring degron network	0.1111
p.E114V	TCGA-AA-3955	COAD	TCGA	VHPYED	LIG_APCC_ABBA_1	119:124	Mutation rewiring degron network	0.1944
p.E114V	DO8232	COAD	ICGC	VHPYED	LIG_APCC_ABBA_1	119:124	Mutation rewiring degron network	0.1944
p.S127R	TCGA-E7-A4IJ	BLCA	TCGA	VHPYED	LIG_APCC_ABBA_1	119:124	Mutation blocking phosphorylation signal	0.6944
p.S127R	DO453	BLCA	ICGC	VHPYED	LIG_APCC_ABBA_1	119:124	Mutation blocking phosphorylation signal	0.6944
p.E123K	TCGA-FS-A1ZA	SKCM	TCGA	VHPYED	LIG_APCC_ABBA_1	119:124	Mutation altering degron motif	0.591
p.E123K	DO37551	SKCM	ICGC	VHPYED	LIG_APCC_ABBA_1	119:124	Mutation altering degron motif	0.591
p.S112F	TCGA-FW-A3R5	SKCM	TCGA	VHPYED	LIG_APCC_ABBA_1	119:124	Mutation blocking phosphorylation signal	0.5833
p.S112F	DO37406	SKCM	ICGC	VHPYED	LIG_APCC_ABBA_1	119:124	Mutation blocking phosphorylation signal	0.5833
p.V119M	DO233212	GACA	ICGC	VHPYED	LIG_APCC_ABBA_1	119:124	Mutation altering degron motif	0.6097
p.S110F	DO222411	MELA	ICGC	VHPYED	LIG_APCC_ABBA_1	119:124	Mutation blocking phosphorylation signal	0.5278
p.E114K	DO229213	THCA	ICGC	VHPYED	LIG_APCC_ABBA_1	119:124	Mutation rewiring degron network	0.1944
p.F113L	DO229213	THCA	ICGC	VHPYED	LIG_APCC_ABBA_1	119:124	Mutation rewiring degron network	0.1667
p.Q119K	ACH-001411	Bladder Cancer	CCLE	VHPYED	LIG_APCC_ABBA_1	119:124	Mutation altering degron motif	0.6944
p.R127K	ACH-002121	Skin Cancer	CCLE	VHPYED	LIG_APCC_ABBA_1	119:124	Mutation blocking phosphorylation signal	0.6944
p.R127K	G-MEL	skin	COSMIC	VHPYED	LIG_APCC_ABBA_1	119:124	Mutation blocking phosphorylation signal	0.6944

Kaplan plot for RIOK3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RIOK3

UniProt ID: O14730

Entrez ID: 8780

Protein name: Serine/threonine-protein kinase RIO3 (EC 2.7.11.1) (RIO kinase 3) (sudD homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RIOK3 in