DegronMD

Uniprot ID: O14730

Source protein: Serine/threonine-protein kinase RIO3

Source gene: RIOK3

Class: LIG_APCC_ABBA_1

Location: 119:124

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9812

ASA_SCORE: 99.5167

COIL: 0.8933

CONS_SCORE: 0.3522

DSS_SCORE: 0.5149

HELIX: 0.047

FCONS_SCORE: 0.8744

RIG_SCORE: 0.6841

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V132I	TCGA-49-6743	LUAD	TCGA	VHPYED	LIG_APCC_ABBA_1	0.1111
p.V132I	DO26092	LUAD	ICGC	VHPYED	LIG_APCC_ABBA_1	0.1111
p.E114V	TCGA-AA-3955	COAD	TCGA	VHPYED	LIG_APCC_ABBA_1	0.1944
p.E114V	DO8232	COAD	ICGC	VHPYED	LIG_APCC_ABBA_1	0.1944
p.S127R	TCGA-E7-A4IJ	BLCA	TCGA	VHPYED	LIG_APCC_ABBA_1	0.6944
p.S127R	DO453	BLCA	ICGC	VHPYED	LIG_APCC_ABBA_1	0.6944
p.E123K	TCGA-FS-A1ZA	SKCM	TCGA	VHPYED	LIG_APCC_ABBA_1	0.591
p.E123K	DO37551	SKCM	ICGC	VHPYED	LIG_APCC_ABBA_1	0.591
p.S112F	TCGA-FW-A3R5	SKCM	TCGA	VHPYED	LIG_APCC_ABBA_1	0.5833
p.S112F	DO37406	SKCM	ICGC	VHPYED	LIG_APCC_ABBA_1	0.5833
p.V119M	DO233212	GACA	ICGC	VHPYED	LIG_APCC_ABBA_1	0.6097
p.S110F	DO222411	MELA	ICGC	VHPYED	LIG_APCC_ABBA_1	0.5278
p.E114K	DO229213	THCA	ICGC	VHPYED	LIG_APCC_ABBA_1	0.1944
p.F113L	DO229213	THCA	ICGC	VHPYED	LIG_APCC_ABBA_1	0.1667
p.Q119K	ACH-001411	Bladder Cancer	CCLE	VHPYED	LIG_APCC_ABBA_1	0.6944
p.R127K	ACH-002121	Skin Cancer	CCLE	VHPYED	LIG_APCC_ABBA_1	0.6944
p.R127K	G-MEL	skin	COSMIC	VHPYED	LIG_APCC_ABBA_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14730	Serine/threonine-protein kinase RIO3	LIG_APCC_ABBA_1	119:124	VHPYED	APC,CDC20,FZR1	0.9812	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons