DegronMD - O14770(MEIS2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R420I	TCGA-19-5956	GBM	TCGA	PQMTPHPT	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.25
p.R420I	DO13863	GBM	ICGC	PQMTPHPT	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.25
p.P409S	TCGA-90-A4ED	LUSC	TCGA	PQMTPHPT	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.3056
p.P409S	TCGA-GN-A267	SKCM	TCGA	PQMTPHPT	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.3056
p.P409S	DO45482	LUSC	ICGC	PQMTPHPT	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.3056
p.P409S	DO38147	SKCM	ICGC	PQMTPHPT	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.3056
p.Y407C	TCGA-A5-A2K5	UCEC	TCGA	PQMTPHPT	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.25
p.Y407C	DO41379	UCEC	ICGC	PQMTPHPT	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.25
p.P416S	TCGA-BH-A0AY	BRCA	TCGA	PQMTPHPT	DEG_SCF_FBW7_1	410:417	Mutation altering degron motif	0.5641
p.P416S	DO5025	BRCA	ICGC	PQMTPHPT	DEG_SCF_FBW7_1	410:417	Mutation altering degron motif	0.5641
p.S427L	TCGA-DA-A3F8	SKCM	TCGA	PQMTPHPT	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.0556
p.S427L	DO37418	SKCM	ICGC	PQMTPHPT	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.0556
p.S406I	TCGA-EY-A215	UCEC	TCGA	PQMTPHPT	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.2222
p.S406I	DO42665	UCEC	ICGC	PQMTPHPT	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.2222
p.H415N	DO228948	LICA	ICGC	PQMTPHPT	DEG_SCF_FBW7_1	410:417	Mutation altering degron motif	0.6312
p.T413N	DO229015	LICA	ICGC	PQMTPHPT	DEG_SCF_FBW7_1	410:417	Mutation altering degron motif	0.7055
p.S401G	SIDM00845	Burkitt's Lymphoma	GDSC	PQMTPHPT	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.0833
p.S401G	SIDM00035	Thyroid Gland Carcinoma	GDSC	PQMTPHPT	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.0833
p.S401G	SIDM00461	Acute Myeloid Leukemia	GDSC	PQMTPHPT	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.0833
p.S401G	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PQMTPHPT	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.0833
p.S401G	SIDM01519	Head and Neck Carcinoma	GDSC	PQMTPHPT	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.0833
p.S401G	DND-41	haematopoietic and lymphoid tissue	COSMIC	PQMTPHPT	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.0833
p.S401G	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PQMTPHPT	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.0833
p.S401G	S-117	soft tissue	COSMIC	PQMTPHPT	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.0833
p.S401G	Daudi	haematopoietic and lymphoid tissue	COSMIC	PQMTPHPT	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.0833
p.M401I	SIDM00510	Small Cell Lung Carcinoma	GDSC	PQMTPHPT	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.0833
p.M401I	COR-L303	lung	COSMIC	PQMTPHPT	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.0833
p.L422F	KOPN-8	haematopoietic and lymphoid tissue	COSMIC	PQMTPHPT	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.1944

Kaplan plot for MEIS2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MEIS2

UniProt ID: O14770

Entrez ID: 4212

Protein name: Homeobox protein Meis2 (Meis1-related protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for MEIS2 in