DegronMD

Uniprot ID: O14770

Source protein: Homeobox protein Meis2

Source gene: MEIS2

Class: DEG_SCF_FBW7_1

Location: 410:417

E3 ligase: FBXW7

DEGRON score: 0.9349

ASA_SCORE: 78.7375

COIL: 0.9195

CONS_SCORE: 0.31

DSS_SCORE: 0.7665

HELIX: 0.0498

FCONS_SCORE: 0.9433

RIG_SCORE: 0.5746

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R420I	TCGA-19-5956	GBM	TCGA	PQMTPHPT	DEG_SCF_FBW7_1	0.25
p.R420I	DO13863	GBM	ICGC	PQMTPHPT	DEG_SCF_FBW7_1	0.25
p.P409S	TCGA-90-A4ED	LUSC	TCGA	PQMTPHPT	DEG_SCF_FBW7_1	0.3056
p.P409S	TCGA-GN-A267	SKCM	TCGA	PQMTPHPT	DEG_SCF_FBW7_1	0.3056
p.P409S	DO45482	LUSC	ICGC	PQMTPHPT	DEG_SCF_FBW7_1	0.3056
p.P409S	DO38147	SKCM	ICGC	PQMTPHPT	DEG_SCF_FBW7_1	0.3056
p.Y407C	TCGA-A5-A2K5	UCEC	TCGA	PQMTPHPT	DEG_SCF_FBW7_1	0.25
p.Y407C	DO41379	UCEC	ICGC	PQMTPHPT	DEG_SCF_FBW7_1	0.25
p.P416S	TCGA-BH-A0AY	BRCA	TCGA	PQMTPHPT	DEG_SCF_FBW7_1	0.5641
p.P416S	DO5025	BRCA	ICGC	PQMTPHPT	DEG_SCF_FBW7_1	0.5641
p.S427L	TCGA-DA-A3F8	SKCM	TCGA	PQMTPHPT	DEG_SCF_FBW7_1	0.0556
p.S427L	DO37418	SKCM	ICGC	PQMTPHPT	DEG_SCF_FBW7_1	0.0556
p.S406I	TCGA-EY-A215	UCEC	TCGA	PQMTPHPT	DEG_SCF_FBW7_1	0.2222
p.S406I	DO42665	UCEC	ICGC	PQMTPHPT	DEG_SCF_FBW7_1	0.2222
p.H415N	DO228948	LICA	ICGC	PQMTPHPT	DEG_SCF_FBW7_1	0.6312
p.T413N	DO229015	LICA	ICGC	PQMTPHPT	DEG_SCF_FBW7_1	0.7055
p.S401G	SIDM00845	Burkitt's Lymphoma	GDSC	PQMTPHPT	DEG_SCF_FBW7_1	0.0833
p.S401G	SIDM00035	Thyroid Gland Carcinoma	GDSC	PQMTPHPT	DEG_SCF_FBW7_1	0.0833
p.S401G	SIDM00461	Acute Myeloid Leukemia	GDSC	PQMTPHPT	DEG_SCF_FBW7_1	0.0833
p.S401G	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PQMTPHPT	DEG_SCF_FBW7_1	0.0833
p.S401G	SIDM01519	Head and Neck Carcinoma	GDSC	PQMTPHPT	DEG_SCF_FBW7_1	0.0833
p.S401G	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PQMTPHPT	DEG_SCF_FBW7_1	0.0833
p.S401G	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PQMTPHPT	DEG_SCF_FBW7_1	0.0833
p.S401G	S-117	soft_tissue	COSMIC	PQMTPHPT	DEG_SCF_FBW7_1	0.0833
p.S401G	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PQMTPHPT	DEG_SCF_FBW7_1	0.0833
p.M401I	SIDM00510	Small Cell Lung Carcinoma	GDSC	PQMTPHPT	DEG_SCF_FBW7_1	0.0833
p.M401I	COR-L303	lung	COSMIC	PQMTPHPT	DEG_SCF_FBW7_1	0.0833
p.L422F	KOPN-8	haematopoietic_and_lymphoid_tissue	COSMIC	PQMTPHPT	DEG_SCF_FBW7_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PQMTPHPT

Degron related mutations and impact score

Drug responses associated with MEIS2 mutations

All proteins holding degron of PQMTPHPT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14770	Homeobox protein Meis2	DEG_SCF_FBW7_1	410:417	PQMTPHPT	FBXW7	0.9349	More...