DegronMD - O14791(APOL1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G296W	TCGA-D3-A2JP	SKCM	TCGA	ARANLQSVP	DEG_APCC_DBOX_1	289:297	Mutation altering degron motif	0.7825
p.G296W	DO47407	SKCM	ICGC	ARANLQSVP	DEG_APCC_DBOX_1	289:297	Mutation altering degron motif	0.7825
p.L282F	TCGA-D6-6516	HNSC	TCGA	ARANLQSVP	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.1389
p.L282F	DO15623	HNSC	ICGC	ARANLQSVP	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.1389
p.D298A	TCGA-ER-A2NG	SKCM	TCGA	ARANLQSVP	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.3056
p.D298A	DO47552	SKCM	ICGC	ARANLQSVP	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.3056
p.N280D	TCGA-FI-A2D5	UCEC	TCGA	ARANLQSVP	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.0833
p.N280D	DO41331	UCEC	ICGC	ARANLQSVP	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.0833
p.R304Q	TCGA-FW-A3R5	SKCM	TCGA	ARANLQSVP	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.1389
p.R304Q	DO37406	SKCM	ICGC	ARANLQSVP	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.1389
p.R293Q	DO222868	MELA	ICGC	ARANLQSVP	DEG_APCC_DBOX_1	289:297	Mutation altering degron motif	0.7329
p.N280K	SIDM00672	Hepatocellular Carcinoma	GDSC	ARANLQSVP	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.0833
p.N280K	SIDM00690	Head and Neck Carcinoma	GDSC	ARANLQSVP	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.0833
p.N280K	SIDM00210	Ovarian Carcinoma	GDSC	ARANLQSVP	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.0833
p.N280K	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	ARANLQSVP	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.0833
p.G286D	SIDM00462	Acute Myeloid Leukemia	GDSC	ARANLQSVP	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.25
p.G286D	SIDM00808	Burkitt's Lymphoma	GDSC	ARANLQSVP	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.25
p.G286D	SIDM01254	Burkitt's Lymphoma	GDSC	ARANLQSVP	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.25
p.L302V	SIDM01757	Bladder Carcinoma	GDSC	ARANLQSVP	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.1944
p.H298Y	ACH-002357	Non-Cancerous	CCLE	ARANLQSVP	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.3056
p.E305Q	LAN-6	autonomic ganglia	COSMIC	ARANLQSVP	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.1111
p.S307N	CTV-1	haematopoietic and lymphoid tissue	COSMIC	ARANLQSVP	DEG_APCC_DBOX_1	289:297	Mutation blocking phosphorylation signal	0.5

Kaplan plot for APOL1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

APOL1

UniProt ID: O14791

Entrez ID: 8542

Protein name: Apolipoprotein L1 (Apolipoprotein L) (Apo-L) (ApoL) (Apolipoprotein L-I) (ApoL-I)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for APOL1 in