DegronMD

Uniprot ID: O14791

Source protein: Apolipoprotein L1

Source gene: APOL1

Class: DEG_APCC_DBOX_1

Location: 289:297

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7257

ASA_SCORE: 51.7111

COIL: 0.3306

CONS_SCORE: 0.4244

DSS_SCORE: 0.4789

HELIX: 0.6374

FCONS_SCORE: 1.1797

RIG_SCORE: 0.6991

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G296W	TCGA-D3-A2JP	SKCM	TCGA	ARANLQSVP	DEG_APCC_DBOX_1	0.7825
p.G296W	DO47407	SKCM	ICGC	ARANLQSVP	DEG_APCC_DBOX_1	0.7825
p.L282F	TCGA-D6-6516	HNSC	TCGA	ARANLQSVP	DEG_APCC_DBOX_1	0.1389
p.L282F	DO15623	HNSC	ICGC	ARANLQSVP	DEG_APCC_DBOX_1	0.1389
p.D298A	TCGA-ER-A2NG	SKCM	TCGA	ARANLQSVP	DEG_APCC_DBOX_1	0.3056
p.D298A	DO47552	SKCM	ICGC	ARANLQSVP	DEG_APCC_DBOX_1	0.3056
p.N280D	TCGA-FI-A2D5	UCEC	TCGA	ARANLQSVP	DEG_APCC_DBOX_1	0.0833
p.N280D	DO41331	UCEC	ICGC	ARANLQSVP	DEG_APCC_DBOX_1	0.0833
p.R304Q	TCGA-FW-A3R5	SKCM	TCGA	ARANLQSVP	DEG_APCC_DBOX_1	0.1389
p.R304Q	DO37406	SKCM	ICGC	ARANLQSVP	DEG_APCC_DBOX_1	0.1389
p.R293Q	DO222868	MELA	ICGC	ARANLQSVP	DEG_APCC_DBOX_1	0.7329
p.N280K	SIDM00672	Hepatocellular Carcinoma	GDSC	ARANLQSVP	DEG_APCC_DBOX_1	0.0833
p.N280K	SIDM00690	Head and Neck Carcinoma	GDSC	ARANLQSVP	DEG_APCC_DBOX_1	0.0833
p.N280K	SIDM00210	Ovarian Carcinoma	GDSC	ARANLQSVP	DEG_APCC_DBOX_1	0.0833
p.N280K	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	ARANLQSVP	DEG_APCC_DBOX_1	0.0833
p.G286D	SIDM00462	Acute Myeloid Leukemia	GDSC	ARANLQSVP	DEG_APCC_DBOX_1	0.25
p.G286D	SIDM00808	Burkitt's Lymphoma	GDSC	ARANLQSVP	DEG_APCC_DBOX_1	0.25
p.G286D	SIDM01254	Burkitt's Lymphoma	GDSC	ARANLQSVP	DEG_APCC_DBOX_1	0.25
p.L302V	SIDM01757	Bladder Carcinoma	GDSC	ARANLQSVP	DEG_APCC_DBOX_1	0.1944
p.H298Y	ACH-002357	Non-Cancerous	CCLE	ARANLQSVP	DEG_APCC_DBOX_1	0.3056
p.E305Q	LAN-6	autonomic_ganglia	COSMIC	ARANLQSVP	DEG_APCC_DBOX_1	0.1111
p.S307N	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	ARANLQSVP	DEG_APCC_DBOX_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14791	Apolipoprotein L1	DEG_APCC_DBOX_1	289:297	ARANLQSVP	APC,CDC20,FZR1	0.7257	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons