DegronMD - O14793(MSTN)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F241L	TCGA-85-8666	LUSC	TCGA	LNPFLE	LIG_APCC_ABBA_1	249:254	Mutation rewiring degron network	0.1111
p.F241L	DO45547	LUSC	ICGC	LNPFLE	LIG_APCC_ABBA_1	249:254	Mutation rewiring degron network	0.1111
p.P251L	TCGA-D3-A2JA	SKCM	TCGA	LNPFLE	LIG_APCC_ABBA_1	249:254	Mutation altering degron motif	0.6471
p.P251L	DO47652	SKCM	ICGC	LNPFLE	LIG_APCC_ABBA_1	249:254	Mutation altering degron motif	0.6471
p.G248W	TCGA-D3-A2JL	SKCM	TCGA	LNPFLE	LIG_APCC_ABBA_1	249:254	Mutation rewiring degron network	0.3056
p.G248W	DO47278	SKCM	ICGC	LNPFLE	LIG_APCC_ABBA_1	249:254	Mutation rewiring degron network	0.3056
p.R263K	TCGA-DK-A6AW	BLCA	TCGA	LNPFLE	LIG_APCC_ABBA_1	249:254	Mutation rewiring degron network	0.0833
p.R263K	DO48566	BLCA	ICGC	LNPFLE	LIG_APCC_ABBA_1	249:254	Mutation rewiring degron network	0.0833
p.P261L	TCGA-EE-A29E	SKCM	TCGA	LNPFLE	LIG_APCC_ABBA_1	249:254	Mutation rewiring degron network	0.1389
p.P261L	DO37831	SKCM	ICGC	LNPFLE	LIG_APCC_ABBA_1	249:254	Mutation rewiring degron network	0.1389
p.P251Q	TCGA-L5-A43C	ESCA	TCGA	LNPFLE	LIG_APCC_ABBA_1	249:254	Mutation altering degron motif	0.7035
p.G243R	TCGA-RC-A7SK	LIHC	TCGA	LNPFLE	LIG_APCC_ABBA_1	249:254	Mutation rewiring degron network	0.1667
p.G243R	DO52314	LIHC	ICGC	LNPFLE	LIG_APCC_ABBA_1	249:254	Mutation rewiring degron network	0.1667
p.L253S	DO222420	MELA	ICGC	LNPFLE	LIG_APCC_ABBA_1	249:254	Mutation altering degron motif	0.6556
p.E254D	SIDM02015	Colorectal Carcinoma	GDSC	LNPFLE	LIG_APCC_ABBA_1	249:254	Mutation altering degron motif	0.5647

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons