DegronMD

Uniprot ID: O14793

Source protein: Growth/differentiation factor 8

Source gene: MSTN

Class: LIG_APCC_ABBA_1

Location: 249:254

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7149

ASA_SCORE: 64.0333

COIL: 0.539

CONS_SCORE: 0.6026

DSS_SCORE: 0.5453

HELIX: 0.0363

FCONS_SCORE: 1.1841

RIG_SCORE: 0.7628

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F241L	TCGA-85-8666	LUSC	TCGA	LNPFLE	LIG_APCC_ABBA_1	0.1111
p.F241L	DO45547	LUSC	ICGC	LNPFLE	LIG_APCC_ABBA_1	0.1111
p.P251L	TCGA-D3-A2JA	SKCM	TCGA	LNPFLE	LIG_APCC_ABBA_1	0.6471
p.P251L	DO47652	SKCM	ICGC	LNPFLE	LIG_APCC_ABBA_1	0.6471
p.G248W	TCGA-D3-A2JL	SKCM	TCGA	LNPFLE	LIG_APCC_ABBA_1	0.3056
p.G248W	DO47278	SKCM	ICGC	LNPFLE	LIG_APCC_ABBA_1	0.3056
p.R263K	TCGA-DK-A6AW	BLCA	TCGA	LNPFLE	LIG_APCC_ABBA_1	0.0833
p.R263K	DO48566	BLCA	ICGC	LNPFLE	LIG_APCC_ABBA_1	0.0833
p.P261L	TCGA-EE-A29E	SKCM	TCGA	LNPFLE	LIG_APCC_ABBA_1	0.1389
p.P261L	DO37831	SKCM	ICGC	LNPFLE	LIG_APCC_ABBA_1	0.1389
p.P251Q	TCGA-L5-A43C	ESCA	TCGA	LNPFLE	LIG_APCC_ABBA_1	0.7035
p.G243R	TCGA-RC-A7SK	LIHC	TCGA	LNPFLE	LIG_APCC_ABBA_1	0.1667
p.G243R	DO52314	LIHC	ICGC	LNPFLE	LIG_APCC_ABBA_1	0.1667
p.L253S	DO222420	MELA	ICGC	LNPFLE	LIG_APCC_ABBA_1	0.6556
p.E254D	SIDM02015	Colorectal Carcinoma	GDSC	LNPFLE	LIG_APCC_ABBA_1	0.5647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14793	Growth/differentiation factor 8	LIG_APCC_ABBA_1	249:254	LNPFLE	APC,CDC20,FZR1	0.7149	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons