DegronMD - O14936(CASK)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E450D	TCGA-D9-A6EC	SKCM	TCGA	LRVTPPPT	DEG_SCF_FBW7_1	457:464	Mutation rewiring degron network	0.1389
p.E450D	DO50291	SKCM	ICGC	LRVTPPPT	DEG_SCF_FBW7_1	457:464	Mutation rewiring degron network	0.1389
p.R458S	TCGA-EE-A3AC	SKCM	TCGA	LRVTPPPT	DEG_SCF_FBW7_1	457:464	Mutation altering degron motif	0.6316
p.R458S	DO37631	SKCM	ICGC	LRVTPPPT	DEG_SCF_FBW7_1	457:464	Mutation altering degron motif	0.6316
p.L468V	TCGA-EO-A3B0	UCEC	TCGA	LRVTPPPT	DEG_SCF_FBW7_1	457:464	Mutation rewiring degron network	0.2222
p.L468V	DO219773	UCEC	ICGC	LRVTPPPT	DEG_SCF_FBW7_1	457:464	Mutation rewiring degron network	0.2222
p.E455K	DO220861	MELA	ICGC	LRVTPPPT	DEG_SCF_FBW7_1	457:464	Mutation rewiring degron network	0.2778
p.S453I	DO50732	ORCA	ICGC	LRVTPPPT	DEG_SCF_FBW7_1	457:464	Mutation rewiring degron network	0.2222
p.P466L	DO218849	SKCA	ICGC	LRVTPPPT	DEG_SCF_FBW7_1	457:464	Mutation rewiring degron network	0.2778
p.G470S	SIDM00447	B-Lymphoblastic Leukemia	GDSC	LRVTPPPT	DEG_SCF_FBW7_1	457:464	Mutation rewiring degron network	0.1667
p.G470S	REH	haematopoietic and lymphoid tissue	COSMIC	LRVTPPPT	DEG_SCF_FBW7_1	457:464	Mutation rewiring degron network	0.1667
p.L457F	SIDM01619	Endometrial Carcinoma	GDSC	LRVTPPPT	DEG_SCF_FBW7_1	457:464	Mutation altering degron motif	0.6981
p.G470D	ACH-000811	Ovarian Cancer	CCLE	LRVTPPPT	DEG_SCF_FBW7_1	457:464	Mutation rewiring degron network	0.1667
p.G464S	ACH-000960	Leukemia	CCLE	LRVTPPPT	DEG_SCF_FBW7_1	457:464	Mutation altering degron motif	0.6993
p.G464S	REH	haematopoietic and lymphoid tissue	COSMIC	LRVTPPPT	DEG_SCF_FBW7_1	457:464	Mutation altering degron motif	0.6993
p.L451F	ACH-000984	Endometrial/Uterine Cancer	CCLE	LRVTPPPT	DEG_SCF_FBW7_1	457:464	Mutation rewiring degron network	0.1667
p.T455A	GP5d	large intestine	COSMIC	LRVTPPPT	DEG_SCF_FBW7_1	457:464	Mutation rewiring degron network	0.2778

Kaplan plot for CASK in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CASK

UniProt ID: O14936

Entrez ID: 8573

Protein name: Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CASK in