DegronMD

Uniprot ID: O14936

Source protein: Peripheral plasma membrane protein CASK

Source gene: CASK

Class: DEG_SCF_FBW7_1

Location: 457:464

E3 ligase: FBXW7

DEGRON score: 0.9708

ASA_SCORE: 89.875

COIL: 0.8926

CONS_SCORE: 0.4369

DSS_SCORE: 0.5612

HELIX: 0.0733

FCONS_SCORE: 1.0745

RIG_SCORE: 0.6727

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E450D	TCGA-D9-A6EC	SKCM	TCGA	LRVTPPPT	DEG_SCF_FBW7_1	0.1389
p.E450D	DO50291	SKCM	ICGC	LRVTPPPT	DEG_SCF_FBW7_1	0.1389
p.R458S	TCGA-EE-A3AC	SKCM	TCGA	LRVTPPPT	DEG_SCF_FBW7_1	0.6316
p.R458S	DO37631	SKCM	ICGC	LRVTPPPT	DEG_SCF_FBW7_1	0.6316
p.L468V	TCGA-EO-A3B0	UCEC	TCGA	LRVTPPPT	DEG_SCF_FBW7_1	0.2222
p.L468V	DO219773	UCEC	ICGC	LRVTPPPT	DEG_SCF_FBW7_1	0.2222
p.E455K	DO220861	MELA	ICGC	LRVTPPPT	DEG_SCF_FBW7_1	0.2778
p.S453I	DO50732	ORCA	ICGC	LRVTPPPT	DEG_SCF_FBW7_1	0.2222
p.P466L	DO218849	SKCA	ICGC	LRVTPPPT	DEG_SCF_FBW7_1	0.2778
p.G470S	SIDM00447	B-Lymphoblastic Leukemia	GDSC	LRVTPPPT	DEG_SCF_FBW7_1	0.1667
p.G470S	REH	haematopoietic_and_lymphoid_tissue	COSMIC	LRVTPPPT	DEG_SCF_FBW7_1	0.1667
p.L457F	SIDM01619	Endometrial Carcinoma	GDSC	LRVTPPPT	DEG_SCF_FBW7_1	0.6981
p.G470D	ACH-000811	Ovarian Cancer	CCLE	LRVTPPPT	DEG_SCF_FBW7_1	0.1667
p.G464S	ACH-000960	Leukemia	CCLE	LRVTPPPT	DEG_SCF_FBW7_1	0.6993
p.G464S	REH	haematopoietic_and_lymphoid_tissue	COSMIC	LRVTPPPT	DEG_SCF_FBW7_1	0.6993
p.L451F	ACH-000984	Endometrial/Uterine Cancer	CCLE	LRVTPPPT	DEG_SCF_FBW7_1	0.1667
p.T455A	GP5d	large_intestine	COSMIC	LRVTPPPT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14936	Peripheral plasma membrane protein CASK	DEG_SCF_FBW7_1	457:464	LRVTPPPT	FBXW7	0.9708	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons