DegronMD - O14950(MYL12B)

MYL12B

Please click HERE for better display.

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M130I	TCGA-17-Z062	LUAD	TCGA	LRELLTTMG	DEG_APCC_DBOX_1	123:131	Mutation altering degron motif	0.6507
p.M130I	DO229037	LICA	ICGC	LRELLTTMG	DEG_APCC_DBOX_1	123:131	Mutation altering degron motif	0.6507
p.T129I	TCGA-AX-A06F	UCEC	TCGA	LRELLTTMG	DEG_APCC_DBOX_1	123:131	Mutation altering degron motif	0.5966
p.T129I	DO41752	UCEC	ICGC	LRELLTTMG	DEG_APCC_DBOX_1	123:131	Mutation altering degron motif	0.5966
p.D136Y	TCGA-B8-A54K	KIRC	TCGA	LRELLTTMG	DEG_APCC_DBOX_1	123:131	Mutation rewiring degron network	0.1944
p.D136Y	DO219234	KIRC	ICGC	LRELLTTMG	DEG_APCC_DBOX_1	123:131	Mutation rewiring degron network	0.1944
p.L127P	TCGA-BR-8487	STAD	TCGA	LRELLTTMG	DEG_APCC_DBOX_1	123:131	Mutation altering degron motif	0.7582
p.L127P	DO47867	STAD	ICGC	LRELLTTMG	DEG_APCC_DBOX_1	123:131	Mutation altering degron motif	0.7582
p.F134L	TCGA-EE-A3J5	SKCM	TCGA	LRELLTTMG	DEG_APCC_DBOX_1	123:131	Mutation rewiring degron network	0.25
p.F134L	DO220878	MELA	ICGC	LRELLTTMG	DEG_APCC_DBOX_1	123:131	Mutation rewiring degron network	0.25
p.F134L	DO47331	SKCM	ICGC	LRELLTTMG	DEG_APCC_DBOX_1	123:131	Mutation rewiring degron network	0.25
p.R124I	TCGA-GN-A265	SKCM	TCGA	LRELLTTMG	DEG_APCC_DBOX_1	123:131	Mutation altering degron motif	0.8102
p.R124I	DO37491	SKCM	ICGC	LRELLTTMG	DEG_APCC_DBOX_1	123:131	Mutation altering degron motif	0.8102
p.D121Y	DO229028	LICA	ICGC	LRELLTTMG	DEG_APCC_DBOX_1	123:131	Mutation rewiring degron network	0.2778
p.G116V	DO229037	LICA	ICGC	LRELLTTMG	DEG_APCC_DBOX_1	123:131	Mutation rewiring degron network	0.1389

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc