DegronMD

Uniprot ID: O14950

Source protein: Myosin regulatory light chain 12B

Source gene: MYL12B

Class: DEG_APCC_DBOX_1

Location: 123:131

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5256

ASA_SCORE: 46.5333

COIL: 0.256

CONS_SCORE: 0.7186

DSS_SCORE: 0.3323

HELIX: 0.7359

FCONS_SCORE: 1.1166

RIG_SCORE: 0.8481

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M130I	TCGA-17-Z062	LUAD	TCGA	LRELLTTMG	DEG_APCC_DBOX_1	0.6507
p.M130I	DO229037	LICA	ICGC	LRELLTTMG	DEG_APCC_DBOX_1	0.6507
p.T129I	TCGA-AX-A06F	UCEC	TCGA	LRELLTTMG	DEG_APCC_DBOX_1	0.5966
p.T129I	DO41752	UCEC	ICGC	LRELLTTMG	DEG_APCC_DBOX_1	0.5966
p.D136Y	TCGA-B8-A54K	KIRC	TCGA	LRELLTTMG	DEG_APCC_DBOX_1	0.1944
p.D136Y	DO219234	KIRC	ICGC	LRELLTTMG	DEG_APCC_DBOX_1	0.1944
p.L127P	TCGA-BR-8487	STAD	TCGA	LRELLTTMG	DEG_APCC_DBOX_1	0.7582
p.L127P	DO47867	STAD	ICGC	LRELLTTMG	DEG_APCC_DBOX_1	0.7582
p.F134L	TCGA-EE-A3J5	SKCM	TCGA	LRELLTTMG	DEG_APCC_DBOX_1	0.25
p.F134L	DO220878	MELA	ICGC	LRELLTTMG	DEG_APCC_DBOX_1	0.25
p.F134L	DO47331	SKCM	ICGC	LRELLTTMG	DEG_APCC_DBOX_1	0.25
p.R124I	TCGA-GN-A265	SKCM	TCGA	LRELLTTMG	DEG_APCC_DBOX_1	0.8102
p.R124I	DO37491	SKCM	ICGC	LRELLTTMG	DEG_APCC_DBOX_1	0.8102
p.D121Y	DO229028	LICA	ICGC	LRELLTTMG	DEG_APCC_DBOX_1	0.2778
p.G116V	DO229037	LICA	ICGC	LRELLTTMG	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14950	Myosin regulatory light chain 12B	DEG_APCC_DBOX_1	123:131	LRELLTTMG	APC,CDC20,FZR1	0.5256	More...
P24844	Myosin regulatory light polypeptide 9	DEG_APCC_DBOX_1	123:131	LRELLTTMG	APC,CDC20,FZR1	0.7085	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons