DegronMD

Uniprot ID: P24844

Source protein: Myosin regulatory light polypeptide 9

Source gene: MYL9

Class: DEG_APCC_DBOX_1

Location: 123:131

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7085

ASA_SCORE: 44.1222

COIL: 0.2597

CONS_SCORE: 0.7109

DSS_SCORE: 0.3179

HELIX: 0.7317

FCONS_SCORE: 1.1107

RIG_SCORE: 0.7966

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M130V	TCGA-2J-AAB6	PAAD	TCGA	LRELLTTMG	DEG_APCC_DBOX_1	0.6097
p.M130V	DO51656	PAAD	ICGC	LRELLTTMG	DEG_APCC_DBOX_1	0.6097
p.M130V	SIDM00500	Colorectal Carcinoma	GDSC	LRELLTTMG	DEG_APCC_DBOX_1	0.6097
p.M130V	ACH-000959	Colon/Colorectal Cancer	CCLE	LRELLTTMG	DEG_APCC_DBOX_1	0.6097
p.F117L	TCGA-AH-6643	READ	TCGA	LRELLTTMG	DEG_APCC_DBOX_1	0.1667
p.E137D	TCGA-AX-A2HC	UCEC	TCGA	LRELLTTMG	DEG_APCC_DBOX_1	0.1667
p.D121A	TCGA-BF-A5ES	SKCM	TCGA	LRELLTTMG	DEG_APCC_DBOX_1	0.2778
p.D121A	DO219456	SKCM	ICGC	LRELLTTMG	DEG_APCC_DBOX_1	0.2778
p.R133H	TCGA-BP-5169	KIRC	TCGA	LRELLTTMG	DEG_APCC_DBOX_1	0.2778
p.E120D	TCGA-DA-A1IB	SKCM	TCGA	LRELLTTMG	DEG_APCC_DBOX_1	0.25
p.E120D	DO38033	SKCM	ICGC	LRELLTTMG	DEG_APCC_DBOX_1	0.25
p.M130I	TCGA-EE-A3AA	SKCM	TCGA	LRELLTTMG	DEG_APCC_DBOX_1	0.6507
p.T129I	TCGA-FW-A3R5	SKCM	TCGA	LRELLTTMG	DEG_APCC_DBOX_1	0.5966
p.T129I	DO37406	SKCM	ICGC	LRELLTTMG	DEG_APCC_DBOX_1	0.5966
p.E137K	TCGA-VS-A958	CESC	TCGA	LRELLTTMG	DEG_APCC_DBOX_1	0.1667
p.F134L	DO228385	LICA	ICGC	LRELLTTMG	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14950	Myosin regulatory light chain 12B	DEG_APCC_DBOX_1	123:131	LRELLTTMG	APC,CDC20,FZR1	0.5256	More...
P24844	Myosin regulatory light polypeptide 9	DEG_APCC_DBOX_1	123:131	LRELLTTMG	APC,CDC20,FZR1	0.7085	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons