DegronMD - P24844(MYL9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M130V	TCGA-2J-AAB6	PAAD	TCGA	LRELLTTMG	DEG_APCC_DBOX_1	123:131	Mutation altering degron motif	0.6097
p.M130V	DO51656	PAAD	ICGC	LRELLTTMG	DEG_APCC_DBOX_1	123:131	Mutation altering degron motif	0.6097
p.M130V	SIDM00500	Colorectal Carcinoma	GDSC	LRELLTTMG	DEG_APCC_DBOX_1	123:131	Mutation altering degron motif	0.6097
p.M130V	ACH-000959	Colon/Colorectal Cancer	CCLE	LRELLTTMG	DEG_APCC_DBOX_1	123:131	Mutation altering degron motif	0.6097
p.F117L	TCGA-AH-6643	READ	TCGA	LRELLTTMG	DEG_APCC_DBOX_1	123:131	Mutation rewiring degron network	0.1667
p.E137D	TCGA-AX-A2HC	UCEC	TCGA	LRELLTTMG	DEG_APCC_DBOX_1	123:131	Mutation rewiring degron network	0.1667
p.D121A	TCGA-BF-A5ES	SKCM	TCGA	LRELLTTMG	DEG_APCC_DBOX_1	123:131	Mutation rewiring degron network	0.2778
p.D121A	DO219456	SKCM	ICGC	LRELLTTMG	DEG_APCC_DBOX_1	123:131	Mutation rewiring degron network	0.2778
p.R133H	TCGA-BP-5169	KIRC	TCGA	LRELLTTMG	DEG_APCC_DBOX_1	123:131	Mutation rewiring degron network	0.2778
p.E120D	TCGA-DA-A1IB	SKCM	TCGA	LRELLTTMG	DEG_APCC_DBOX_1	123:131	Mutation rewiring degron network	0.25
p.E120D	DO38033	SKCM	ICGC	LRELLTTMG	DEG_APCC_DBOX_1	123:131	Mutation rewiring degron network	0.25
p.M130I	TCGA-EE-A3AA	SKCM	TCGA	LRELLTTMG	DEG_APCC_DBOX_1	123:131	Mutation altering degron motif	0.6507
p.T129I	TCGA-FW-A3R5	SKCM	TCGA	LRELLTTMG	DEG_APCC_DBOX_1	123:131	Mutation altering degron motif	0.5966
p.T129I	DO37406	SKCM	ICGC	LRELLTTMG	DEG_APCC_DBOX_1	123:131	Mutation altering degron motif	0.5966
p.E137K	TCGA-VS-A958	CESC	TCGA	LRELLTTMG	DEG_APCC_DBOX_1	123:131	Mutation rewiring degron network	0.1667
p.F134L	DO228385	LICA	ICGC	LRELLTTMG	DEG_APCC_DBOX_1	123:131	Mutation rewiring degron network	0.25

Kaplan plot for MYL9 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYL9

UniProt ID: P24844

Entrez ID: 10398

Protein name: Myosin regulatory light polypeptide 9 (20 kDa myosin light chain) (LC20) (MLC-2C) (Myosin RLC) (Myosin regulatory light chain 2, smooth muscle isoform) (Myosin regulatory light chain 9) (Myosin regulatory light chain MRLC1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYL9 in