DegronMD - O14958(CASQ2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E255K	TCGA-AN-A046	BRCA	TCGA	QRPTLRRLR	DEG_APCC_DBOX_1	245:253	Mutation rewiring degron network	0.2778
p.R251H	TCGA-B5-A11E	UCEC	TCGA	QRPTLRRLR	DEG_APCC_DBOX_1	245:253	Mutation altering degron motif	0.7133
p.R251H	ACH-001128	Rhabdoid	CCLE	QRPTLRRLR	DEG_APCC_DBOX_1	245:253	Mutation altering degron motif	0.7133
p.D263N	TCGA-BT-A2LA	BLCA	TCGA	QRPTLRRLR	DEG_APCC_DBOX_1	245:253	Mutation rewiring degron network	0.0556
p.D263N	DO561	BLCA	ICGC	QRPTLRRLR	DEG_APCC_DBOX_1	245:253	Mutation rewiring degron network	0.0556
p.R250C	TCGA-VQ-A8P2	STAD	TCGA	QRPTLRRLR	DEG_APCC_DBOX_1	245:253	Mutation altering degron motif	0.719
p.F256L	DO225367	BRCA	ICGC	QRPTLRRLR	DEG_APCC_DBOX_1	245:253	Mutation rewiring degron network	0.25
p.F256L	DO228937	LICA	ICGC	QRPTLRRLR	DEG_APCC_DBOX_1	245:253	Mutation rewiring degron network	0.25
p.L237M	DO229024	LICA	ICGC	QRPTLRRLR	DEG_APCC_DBOX_1	245:253	Mutation rewiring degron network	0.1111
p.P237Q	DO229037	LICA	ICGC	QRPTLRRLR	DEG_APCC_DBOX_1	245:253	Mutation rewiring degron network	0.1111
p.P237Q	DO231070	LUSC	ICGC	QRPTLRRLR	DEG_APCC_DBOX_1	245:253	Mutation rewiring degron network	0.1111
p.D236N	DO36881	READ	ICGC	QRPTLRRLR	DEG_APCC_DBOX_1	245:253	Mutation rewiring degron network	0.0833
p.D236N	DO42129	UCEC	ICGC	QRPTLRRLR	DEG_APCC_DBOX_1	245:253	Mutation rewiring degron network	0.0833
p.D236N	DO41572	UCEC	ICGC	QRPTLRRLR	DEG_APCC_DBOX_1	245:253	Mutation rewiring degron network	0.0833
p.P241H	DO37571	SKCM	ICGC	QRPTLRRLR	DEG_APCC_DBOX_1	245:253	Mutation rewiring degron network	0.2222
p.W247L	DO37420	SKCM	ICGC	QRPTLRRLR	DEG_APCC_DBOX_1	245:253	Mutation altering degron motif	0.7015
p.W247L	DO47683	SKCM	ICGC	QRPTLRRLR	DEG_APCC_DBOX_1	245:253	Mutation altering degron motif	0.7015
p.W247L	DO47569	SKCM	ICGC	QRPTLRRLR	DEG_APCC_DBOX_1	245:253	Mutation altering degron motif	0.7015
p.R251C	DO229213	THCA	ICGC	QRPTLRRLR	DEG_APCC_DBOX_1	245:253	Mutation altering degron motif	0.719
p.E248D	DO41488	UCEC	ICGC	QRPTLRRLR	DEG_APCC_DBOX_1	245:253	Mutation altering degron motif	0.6758
p.H244R	SIDM00969	Ovarian Carcinoma	GDSC	QRPTLRRLR	DEG_APCC_DBOX_1	245:253	Mutation rewiring degron network	0.3056
p.H244R	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	QRPTLRRLR	DEG_APCC_DBOX_1	245:253	Mutation rewiring degron network	0.3056
p.H244R	SIDM00720	Mesothelioma	GDSC	QRPTLRRLR	DEG_APCC_DBOX_1	245:253	Mutation rewiring degron network	0.3056
p.H244R	SIDM00673	Breast Carcinoma	GDSC	QRPTLRRLR	DEG_APCC_DBOX_1	245:253	Mutation rewiring degron network	0.3056
p.H244R	SIDM00785	Acute Myeloid Leukemia	GDSC	QRPTLRRLR	DEG_APCC_DBOX_1	245:253	Mutation rewiring degron network	0.3056
p.H244R	SIDM01318	Hepatocellular Carcinoma	GDSC	QRPTLRRLR	DEG_APCC_DBOX_1	245:253	Mutation rewiring degron network	0.3056
p.H244R	SIDM01752	Pancreatic Carcinoma	GDSC	QRPTLRRLR	DEG_APCC_DBOX_1	245:253	Mutation rewiring degron network	0.3056
p.H244Y	SIDM00969	Ovarian Carcinoma	GDSC	QRPTLRRLR	DEG_APCC_DBOX_1	245:253	Mutation rewiring degron network	0.3056
p.H244Y	DOV13	ovary	COSMIC	QRPTLRRLR	DEG_APCC_DBOX_1	245:253	Mutation rewiring degron network	0.3056
p.V238L	ACH-000872	Lung Cancer	CCLE	QRPTLRRLR	DEG_APCC_DBOX_1	245:253	Mutation rewiring degron network	0.1389

Kaplan plot for CASQ2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CASQ2

UniProt ID: O14958

Entrez ID: 845

Protein name: Calsequestrin-2 (Calsequestrin, cardiac muscle isoform)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CASQ2 in