DegronMD

Uniprot ID: O14958

Source protein: Calsequestrin-2

Source gene: CASQ2

Class: DEG_APCC_DBOX_1

Location: 245:253

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9284

ASA_SCORE: 79.1333

COIL: 0.7683

CONS_SCORE: 0.4916

DSS_SCORE: 0.3693

HELIX: 0.04

FCONS_SCORE: 1.0362

RIG_SCORE: 0.7837

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E255K	TCGA-AN-A046	BRCA	TCGA	QRPTLRRLR	DEG_APCC_DBOX_1	0.2778
p.R251H	TCGA-B5-A11E	UCEC	TCGA	QRPTLRRLR	DEG_APCC_DBOX_1	0.7133
p.R251H	ACH-001128	Rhabdoid	CCLE	QRPTLRRLR	DEG_APCC_DBOX_1	0.7133
p.D263N	TCGA-BT-A2LA	BLCA	TCGA	QRPTLRRLR	DEG_APCC_DBOX_1	0.0556
p.D263N	DO561	BLCA	ICGC	QRPTLRRLR	DEG_APCC_DBOX_1	0.0556
p.R250C	TCGA-VQ-A8P2	STAD	TCGA	QRPTLRRLR	DEG_APCC_DBOX_1	0.719
p.F256L	DO225367	BRCA	ICGC	QRPTLRRLR	DEG_APCC_DBOX_1	0.25
p.F256L	DO228937	LICA	ICGC	QRPTLRRLR	DEG_APCC_DBOX_1	0.25
p.L237M	DO229024	LICA	ICGC	QRPTLRRLR	DEG_APCC_DBOX_1	0.1111
p.P237Q	DO229037	LICA	ICGC	QRPTLRRLR	DEG_APCC_DBOX_1	0.1111
p.P237Q	DO231070	LUSC	ICGC	QRPTLRRLR	DEG_APCC_DBOX_1	0.1111
p.D236N	DO36881	READ	ICGC	QRPTLRRLR	DEG_APCC_DBOX_1	0.0833
p.D236N	DO42129	UCEC	ICGC	QRPTLRRLR	DEG_APCC_DBOX_1	0.0833
p.D236N	DO41572	UCEC	ICGC	QRPTLRRLR	DEG_APCC_DBOX_1	0.0833
p.P241H	DO37571	SKCM	ICGC	QRPTLRRLR	DEG_APCC_DBOX_1	0.2222
p.W247L	DO37420	SKCM	ICGC	QRPTLRRLR	DEG_APCC_DBOX_1	0.7015
p.W247L	DO47683	SKCM	ICGC	QRPTLRRLR	DEG_APCC_DBOX_1	0.7015
p.W247L	DO47569	SKCM	ICGC	QRPTLRRLR	DEG_APCC_DBOX_1	0.7015
p.R251C	DO229213	THCA	ICGC	QRPTLRRLR	DEG_APCC_DBOX_1	0.719
p.E248D	DO41488	UCEC	ICGC	QRPTLRRLR	DEG_APCC_DBOX_1	0.6758
p.H244R	SIDM00969	Ovarian Carcinoma	GDSC	QRPTLRRLR	DEG_APCC_DBOX_1	0.3056
p.H244R	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	QRPTLRRLR	DEG_APCC_DBOX_1	0.3056
p.H244R	SIDM00720	Mesothelioma	GDSC	QRPTLRRLR	DEG_APCC_DBOX_1	0.3056
p.H244R	SIDM00673	Breast Carcinoma	GDSC	QRPTLRRLR	DEG_APCC_DBOX_1	0.3056
p.H244R	SIDM00785	Acute Myeloid Leukemia	GDSC	QRPTLRRLR	DEG_APCC_DBOX_1	0.3056
p.H244R	SIDM01318	Hepatocellular Carcinoma	GDSC	QRPTLRRLR	DEG_APCC_DBOX_1	0.3056
p.H244R	SIDM01752	Pancreatic Carcinoma	GDSC	QRPTLRRLR	DEG_APCC_DBOX_1	0.3056
p.H244Y	SIDM00969	Ovarian Carcinoma	GDSC	QRPTLRRLR	DEG_APCC_DBOX_1	0.3056
p.H244Y	DOV13	ovary	COSMIC	QRPTLRRLR	DEG_APCC_DBOX_1	0.3056
p.V238L	ACH-000872	Lung Cancer	CCLE	QRPTLRRLR	DEG_APCC_DBOX_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QRPTLRRLR

Degron related mutations and impact score

Drug responses associated with CASQ2 mutations

All proteins holding degron of QRPTLRRLR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14958	Calsequestrin-2	DEG_APCC_DBOX_1	245:253	QRPTLRRLR	APC,CDC20,FZR1	0.9284	More...