DegronMD - O14975(SLC27A2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R523C	TCGA-AA-3510	COAD	TCGA	MKENH	DEG_APCC_KENBOX_2	531:535	Mutation rewiring degron network	0.1111
p.R523C	TCGA-AP-A1DV	UCEC	TCGA	MKENH	DEG_APCC_KENBOX_2	531:535	Mutation rewiring degron network	0.1111
p.R523C	TCGA-C5-A1M7	CESC	TCGA	MKENH	DEG_APCC_KENBOX_2	531:535	Mutation rewiring degron network	0.1111
p.R523C	DO48981	CESC	ICGC	MKENH	DEG_APCC_KENBOX_2	531:535	Mutation rewiring degron network	0.1111
p.R523C	DO7783	COAD	ICGC	MKENH	DEG_APCC_KENBOX_2	531:535	Mutation rewiring degron network	0.1111
p.R523C	DO43186	UCEC	ICGC	MKENH	DEG_APCC_KENBOX_2	531:535	Mutation rewiring degron network	0.1111
p.R523C	SIDM00217	Colorectal Carcinoma	GDSC	MKENH	DEG_APCC_KENBOX_2	531:535	Mutation rewiring degron network	0.1111
p.R523C	SNU-1040	large intestine	COSMIC	MKENH	DEG_APCC_KENBOX_2	531:535	Mutation rewiring degron network	0.1111
p.N534S	TCGA-BH-A0HA	BRCA	TCGA	MKENH	DEG_APCC_KENBOX_2	531:535	Mutation altering degron motif	0.7069
p.N534S	DO1658	BRCA	ICGC	MKENH	DEG_APCC_KENBOX_2	531:535	Mutation altering degron motif	0.7069
p.E533Q	TCGA-BT-A42C	BLCA	TCGA	MKENH	DEG_APCC_KENBOX_2	531:535	Mutation altering degron motif	0.6744
p.E533Q	DO49725	BLCA	ICGC	MKENH	DEG_APCC_KENBOX_2	531:535	Mutation altering degron motif	0.6744
p.E536K	TCGA-EB-A3XD	SKCM	TCGA	MKENH	DEG_APCC_KENBOX_2	531:535	Mutation rewiring degron network	0.3056
p.E536K	DO37871	SKCM	ICGC	MKENH	DEG_APCC_KENBOX_2	531:535	Mutation rewiring degron network	0.3056
p.R523H	TCGA-F4-6856	COAD	TCGA	MKENH	DEG_APCC_KENBOX_2	531:535	Mutation rewiring degron network	0.1111
p.R523H	DO9114	COAD	ICGC	MKENH	DEG_APCC_KENBOX_2	531:535	Mutation rewiring degron network	0.1111
p.F543L	TCGA-NC-A5HN	LUSC	TCGA	MKENH	DEG_APCC_KENBOX_2	531:535	Mutation rewiring degron network	0.1111
p.F543L	DO52025	LUSC	ICGC	MKENH	DEG_APCC_KENBOX_2	531:535	Mutation rewiring degron network	0.1111
p.G539R	TCGA-S9-A6U6	LGG	TCGA	MKENH	DEG_APCC_KENBOX_2	531:535	Mutation rewiring degron network	0.2222
p.G539R	DO50190	LGG	ICGC	MKENH	DEG_APCC_KENBOX_2	531:535	Mutation rewiring degron network	0.2222
p.M531I	DO229456	SKCA	ICGC	MKENH	DEG_APCC_KENBOX_2	531:535	Mutation altering degron motif	0.6507
p.I524T	SIDM00193	Colorectal Carcinoma	GDSC	MKENH	DEG_APCC_KENBOX_2	531:535	Mutation rewiring degron network	0.1389
p.I524T	SNU-81	large intestine	COSMIC	MKENH	DEG_APCC_KENBOX_2	531:535	Mutation rewiring degron network	0.1389
p.A533V	LS-411N	large intestine	COSMIC	MKENH	DEG_APCC_KENBOX_2	531:535	Mutation altering degron motif	0.6936

Kaplan plot for SLC27A2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC27A2

UniProt ID: O14975

Entrez ID: 11001

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLC27A2 in