DegronMD

Uniprot ID: O14975

Source protein: Very long-chain acyl-CoA synthetase

Source gene: SLC27A2

Class: DEG_APCC_KENBOX_2

Location: 531:535

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5907

ASA_SCORE: 86.94

COIL: 0.7946

CONS_SCORE: 0.4366

DSS_SCORE: 0.2801

HELIX: 0.023

FCONS_SCORE: 0.876

RIG_SCORE: 0.7546

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R523C	TCGA-AA-3510	COAD	TCGA	MKENH	DEG_APCC_KENBOX_2	0.1111
p.R523C	TCGA-AP-A1DV	UCEC	TCGA	MKENH	DEG_APCC_KENBOX_2	0.1111
p.R523C	TCGA-C5-A1M7	CESC	TCGA	MKENH	DEG_APCC_KENBOX_2	0.1111
p.R523C	DO48981	CESC	ICGC	MKENH	DEG_APCC_KENBOX_2	0.1111
p.R523C	DO7783	COAD	ICGC	MKENH	DEG_APCC_KENBOX_2	0.1111
p.R523C	DO43186	UCEC	ICGC	MKENH	DEG_APCC_KENBOX_2	0.1111
p.R523C	SIDM00217	Colorectal Carcinoma	GDSC	MKENH	DEG_APCC_KENBOX_2	0.1111
p.R523C	SNU-1040	large_intestine	COSMIC	MKENH	DEG_APCC_KENBOX_2	0.1111
p.N534S	TCGA-BH-A0HA	BRCA	TCGA	MKENH	DEG_APCC_KENBOX_2	0.7069
p.N534S	DO1658	BRCA	ICGC	MKENH	DEG_APCC_KENBOX_2	0.7069
p.E533Q	TCGA-BT-A42C	BLCA	TCGA	MKENH	DEG_APCC_KENBOX_2	0.6744
p.E533Q	DO49725	BLCA	ICGC	MKENH	DEG_APCC_KENBOX_2	0.6744
p.E536K	TCGA-EB-A3XD	SKCM	TCGA	MKENH	DEG_APCC_KENBOX_2	0.3056
p.E536K	DO37871	SKCM	ICGC	MKENH	DEG_APCC_KENBOX_2	0.3056
p.R523H	TCGA-F4-6856	COAD	TCGA	MKENH	DEG_APCC_KENBOX_2	0.1111
p.R523H	DO9114	COAD	ICGC	MKENH	DEG_APCC_KENBOX_2	0.1111
p.F543L	TCGA-NC-A5HN	LUSC	TCGA	MKENH	DEG_APCC_KENBOX_2	0.1111
p.F543L	DO52025	LUSC	ICGC	MKENH	DEG_APCC_KENBOX_2	0.1111
p.G539R	TCGA-S9-A6U6	LGG	TCGA	MKENH	DEG_APCC_KENBOX_2	0.2222
p.G539R	DO50190	LGG	ICGC	MKENH	DEG_APCC_KENBOX_2	0.2222
p.M531I	DO229456	SKCA	ICGC	MKENH	DEG_APCC_KENBOX_2	0.6507
p.I524T	SIDM00193	Colorectal Carcinoma	GDSC	MKENH	DEG_APCC_KENBOX_2	0.1389
p.I524T	SNU-81	large_intestine	COSMIC	MKENH	DEG_APCC_KENBOX_2	0.1389
p.A533V	LS-411N	large_intestine	COSMIC	MKENH	DEG_APCC_KENBOX_2	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14975	Very long-chain acyl-CoA synthetase	DEG_APCC_KENBOX_2	531:535	MKENH	APC,CDC20,FZR1	0.5907	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons