DegronMD - O14978(ZNF263)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E9K	TCGA-AP-A1DV	UCEC	TCGA	EREGLLIVK	DEG_APCC_DBOX_1	9:17	Mutation altering degron motif	0.591
p.E9K	DO43186	UCEC	ICGC	EREGLLIVK	DEG_APCC_DBOX_1	9:17	Mutation altering degron motif	0.591
p.E27G	TCGA-CK-6746	COAD	TCGA	EREGLLIVK	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.0556
p.E27G	DO7938	COAD	ICGC	EREGLLIVK	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.0556
p.A2S	TCGA-DX-A7ES	SARC	TCGA	EREGLLIVK	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.1389
p.A2S	DO220036	SARC	ICGC	EREGLLIVK	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.1389
p.P5T	TCGA-EY-A1GQ	UCEC	TCGA	EREGLLIVK	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.2222
p.P5T	DO43090	UCEC	ICGC	EREGLLIVK	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.2222
p.S7F	TCGA-FJ-A3Z7	BLCA	TCGA	EREGLLIVK	DEG_APCC_DBOX_1	9:17	Mutation blocking phosphorylation signal	0.7222
p.S7F	DO463	BLCA	ICGC	EREGLLIVK	DEG_APCC_DBOX_1	9:17	Mutation blocking phosphorylation signal	0.7222
p.A23T	TCGA-IB-7651	PAAD	TCGA	EREGLLIVK	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.1667
p.A23T	DO46657	PAAD	ICGC	EREGLLIVK	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.1667
p.G12W	TCGA-VQ-A8P2	STAD	TCGA	EREGLLIVK	DEG_APCC_DBOX_1	9:17	Mutation altering degron motif	0.6714
p.G12W	DO51761	STAD	ICGC	EREGLLIVK	DEG_APCC_DBOX_1	9:17	Mutation altering degron motif	0.6714
p.A23S	DO222629	BTCA	ICGC	EREGLLIVK	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.1667
p.E19D	DO229027	LICA	ICGC	EREGLLIVK	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.2778
p.V16L	DO229041	LICA	ICGC	EREGLLIVK	DEG_APCC_DBOX_1	9:17	Mutation altering degron motif	0.5654
p.L5F	DO229009	LICA	ICGC	EREGLLIVK	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.2222
p.P17Q	DO37810	SKCM	ICGC	EREGLLIVK	DEG_APCC_DBOX_1	9:17	Mutation altering degron motif	0.7035
p.R16Q	DO41871	UCEC	ICGC	EREGLLIVK	DEG_APCC_DBOX_1	9:17	Mutation altering degron motif	0.7329
p.E20D	SIDM00529	Breast Carcinoma	GDSC	EREGLLIVK	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.25
p.S25R	SIDM00294	Small Cell Lung Carcinoma	GDSC	EREGLLIVK	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.1111
p.S25R	ACH-001549	Lung Cancer	CCLE	EREGLLIVK	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.1111
p.S25R	LU-135	lung	COSMIC	EREGLLIVK	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.1111
p.L25F	RCC-MF	kidney	COSMIC	EREGLLIVK	DEG_APCC_DBOX_1	9:17	Mutation rewiring degron network	0.1111

Kaplan plot for ZNF263 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF263

UniProt ID: O14978

Entrez ID: 10127

Protein name: Zinc finger protein 263 (Zinc finger protein FPM315) (Zinc finger protein with KRAB and SCAN domains 12)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF263 in