DegronMD

Uniprot ID: O14978

Source protein: Zinc finger protein 263

Source gene: ZNF263

Class: DEG_APCC_DBOX_1

Location: 9:17

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9591

ASA_SCORE: 91.6333

COIL: 0.5804

CONS_SCORE: 0.6666

DSS_SCORE: 0.6077

HELIX: 0.0988

FCONS_SCORE: 1.3066

RIG_SCORE: 0.7641

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E9K	TCGA-AP-A1DV	UCEC	TCGA	EREGLLIVK	DEG_APCC_DBOX_1	0.591
p.E9K	DO43186	UCEC	ICGC	EREGLLIVK	DEG_APCC_DBOX_1	0.591
p.E27G	TCGA-CK-6746	COAD	TCGA	EREGLLIVK	DEG_APCC_DBOX_1	0.0556
p.E27G	DO7938	COAD	ICGC	EREGLLIVK	DEG_APCC_DBOX_1	0.0556
p.A2S	TCGA-DX-A7ES	SARC	TCGA	EREGLLIVK	DEG_APCC_DBOX_1	0.1389
p.A2S	DO220036	SARC	ICGC	EREGLLIVK	DEG_APCC_DBOX_1	0.1389
p.P5T	TCGA-EY-A1GQ	UCEC	TCGA	EREGLLIVK	DEG_APCC_DBOX_1	0.2222
p.P5T	DO43090	UCEC	ICGC	EREGLLIVK	DEG_APCC_DBOX_1	0.2222
p.S7F	TCGA-FJ-A3Z7	BLCA	TCGA	EREGLLIVK	DEG_APCC_DBOX_1	0.7222
p.S7F	DO463	BLCA	ICGC	EREGLLIVK	DEG_APCC_DBOX_1	0.7222
p.A23T	TCGA-IB-7651	PAAD	TCGA	EREGLLIVK	DEG_APCC_DBOX_1	0.1667
p.A23T	DO46657	PAAD	ICGC	EREGLLIVK	DEG_APCC_DBOX_1	0.1667
p.G12W	TCGA-VQ-A8P2	STAD	TCGA	EREGLLIVK	DEG_APCC_DBOX_1	0.6714
p.G12W	DO51761	STAD	ICGC	EREGLLIVK	DEG_APCC_DBOX_1	0.6714
p.A23S	DO222629	BTCA	ICGC	EREGLLIVK	DEG_APCC_DBOX_1	0.1667
p.E19D	DO229027	LICA	ICGC	EREGLLIVK	DEG_APCC_DBOX_1	0.2778
p.V16L	DO229041	LICA	ICGC	EREGLLIVK	DEG_APCC_DBOX_1	0.5654
p.L5F	DO229009	LICA	ICGC	EREGLLIVK	DEG_APCC_DBOX_1	0.2222
p.P17Q	DO37810	SKCM	ICGC	EREGLLIVK	DEG_APCC_DBOX_1	0.7035
p.R16Q	DO41871	UCEC	ICGC	EREGLLIVK	DEG_APCC_DBOX_1	0.7329
p.E20D	SIDM00529	Breast Carcinoma	GDSC	EREGLLIVK	DEG_APCC_DBOX_1	0.25
p.S25R	SIDM00294	Small Cell Lung Carcinoma	GDSC	EREGLLIVK	DEG_APCC_DBOX_1	0.1111
p.S25R	ACH-001549	Lung Cancer	CCLE	EREGLLIVK	DEG_APCC_DBOX_1	0.1111
p.S25R	LU-135	lung	COSMIC	EREGLLIVK	DEG_APCC_DBOX_1	0.1111
p.L25F	RCC-MF	kidney	COSMIC	EREGLLIVK	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14978	Zinc finger protein 263	DEG_APCC_DBOX_1	9:17	EREGLLIVK	APC,CDC20,FZR1	0.9591	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons