DegronMD - O15031(PLXNB2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G943W	TCGA-BQ-7059	KIRP	TCGA	VRVTLNGVP	DEG_APCC_DBOX_1	928:936	Mutation rewiring degron network	0.1389
p.G943W	DO20932	KIRP	ICGC	VRVTLNGVP	DEG_APCC_DBOX_1	928:936	Mutation rewiring degron network	0.1389
p.C937F	TCGA-FD-A43Y	BLCA	TCGA	VRVTLNGVP	DEG_APCC_DBOX_1	928:936	Mutation rewiring degron network	0.3056
p.C937F	DO44071	BLCA	ICGC	VRVTLNGVP	DEG_APCC_DBOX_1	928:936	Mutation rewiring degron network	0.3056
p.V935I	DO229346	LAML	ICGC	VRVTLNGVP	DEG_APCC_DBOX_1	928:936	Mutation altering degron motif	0.5965
p.V935I	DO228941	LICA	ICGC	VRVTLNGVP	DEG_APCC_DBOX_1	928:936	Mutation altering degron motif	0.5965
p.H919Q	DO229026	LICA	ICGC	VRVTLNGVP	DEG_APCC_DBOX_1	928:936	Mutation rewiring degron network	0.0833
p.A944V	DO50948	LICA	ICGC	VRVTLNGVP	DEG_APCC_DBOX_1	928:936	Mutation rewiring degron network	0.1111
p.A944V	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	VRVTLNGVP	DEG_APCC_DBOX_1	928:936	Mutation rewiring degron network	0.1111
p.A944V	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	VRVTLNGVP	DEG_APCC_DBOX_1	928:936	Mutation rewiring degron network	0.1111
p.A944V	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	VRVTLNGVP	DEG_APCC_DBOX_1	928:936	Mutation rewiring degron network	0.1111
p.A944V	SIDM01525	Acute Myeloid Leukemia	GDSC	VRVTLNGVP	DEG_APCC_DBOX_1	928:936	Mutation rewiring degron network	0.1111
p.Q925K	DO231179	LUSC	ICGC	VRVTLNGVP	DEG_APCC_DBOX_1	928:936	Mutation rewiring degron network	0.25
p.L932F	DO222418	MELA	ICGC	VRVTLNGVP	DEG_APCC_DBOX_1	928:936	Mutation altering degron motif	0.6981
p.R929W	DO233294	NACA	ICGC	VRVTLNGVP	DEG_APCC_DBOX_1	928:936	Mutation altering degron motif	0.8634
p.R929W	DO228138	PBCA	ICGC	VRVTLNGVP	DEG_APCC_DBOX_1	928:936	Mutation altering degron motif	0.8634
p.F942S	DO32936	PACA	ICGC	VRVTLNGVP	DEG_APCC_DBOX_1	928:936	Mutation rewiring degron network	0.1667
p.T931I	SIDM00274	Gastric Carcinoma	GDSC	VRVTLNGVP	DEG_APCC_DBOX_1	928:936	Mutation altering degron motif	0.5966
p.T931I	ACH-000047	Gastric Cancer	CCLE	VRVTLNGVP	DEG_APCC_DBOX_1	928:936	Mutation altering degron motif	0.5966
p.T931I	GCIY	stomach	COSMIC	VRVTLNGVP	DEG_APCC_DBOX_1	928:936	Mutation altering degron motif	0.5966

Kaplan plot for PLXNB2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLXNB2

UniProt ID: O15031

Entrez ID: 23654

Protein name: Plexin-B2 (MM1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLXNB2 in