DegronMD

Uniprot ID: O15031

Source protein: Plexin-B2

Source gene: PLXNB2

Class: DEG_APCC_DBOX_1

Location: 928:936

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8872

ASA_SCORE: 51.0889

COIL: 0.315

CONS_SCORE: 0.4816

DSS_SCORE: 0.3317

HELIX: 0.0074

FCONS_SCORE: 0.8821

RIG_SCORE: 0.8167

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G943W	TCGA-BQ-7059	KIRP	TCGA	VRVTLNGVP	DEG_APCC_DBOX_1	0.1389
p.G943W	DO20932	KIRP	ICGC	VRVTLNGVP	DEG_APCC_DBOX_1	0.1389
p.C937F	TCGA-FD-A43Y	BLCA	TCGA	VRVTLNGVP	DEG_APCC_DBOX_1	0.3056
p.C937F	DO44071	BLCA	ICGC	VRVTLNGVP	DEG_APCC_DBOX_1	0.3056
p.V935I	DO229346	LAML	ICGC	VRVTLNGVP	DEG_APCC_DBOX_1	0.5965
p.V935I	DO228941	LICA	ICGC	VRVTLNGVP	DEG_APCC_DBOX_1	0.5965
p.H919Q	DO229026	LICA	ICGC	VRVTLNGVP	DEG_APCC_DBOX_1	0.0833
p.A944V	DO50948	LICA	ICGC	VRVTLNGVP	DEG_APCC_DBOX_1	0.1111
p.A944V	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	VRVTLNGVP	DEG_APCC_DBOX_1	0.1111
p.A944V	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	VRVTLNGVP	DEG_APCC_DBOX_1	0.1111
p.A944V	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	VRVTLNGVP	DEG_APCC_DBOX_1	0.1111
p.A944V	SIDM01525	Acute Myeloid Leukemia	GDSC	VRVTLNGVP	DEG_APCC_DBOX_1	0.1111
p.Q925K	DO231179	LUSC	ICGC	VRVTLNGVP	DEG_APCC_DBOX_1	0.25
p.L932F	DO222418	MELA	ICGC	VRVTLNGVP	DEG_APCC_DBOX_1	0.6981
p.R929W	DO233294	NACA	ICGC	VRVTLNGVP	DEG_APCC_DBOX_1	0.8634
p.R929W	DO228138	PBCA	ICGC	VRVTLNGVP	DEG_APCC_DBOX_1	0.8634
p.F942S	DO32936	PACA	ICGC	VRVTLNGVP	DEG_APCC_DBOX_1	0.1667
p.T931I	SIDM00274	Gastric Carcinoma	GDSC	VRVTLNGVP	DEG_APCC_DBOX_1	0.5966
p.T931I	ACH-000047	Gastric Cancer	CCLE	VRVTLNGVP	DEG_APCC_DBOX_1	0.5966
p.T931I	GCIY	stomach	COSMIC	VRVTLNGVP	DEG_APCC_DBOX_1	0.5966

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15031	Plexin-B2	DEG_APCC_DBOX_1	928:936	VRVTLNGVP	APC,CDC20,FZR1	0.8872	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons