DegronMD - O15050(TRANK1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K935E	TCGA-64-1679	LUAD	TCGA	LRKKLKGIN	DEG_APCC_DBOX_1	926:934	Mutation rewiring degron network	0.3056
p.K935E	DO26200	LUAD	ICGC	LRKKLKGIN	DEG_APCC_DBOX_1	926:934	Mutation rewiring degron network	0.3056
p.R927W	TCGA-D5-6928	COAD	TCGA	LRKKLKGIN	DEG_APCC_DBOX_1	926:934	Mutation altering degron motif	0.8634
p.R927W	TCGA-DK-AA77	BLCA	TCGA	LRKKLKGIN	DEG_APCC_DBOX_1	926:934	Mutation altering degron motif	0.8634
p.R927W	DO219014	BLCA	ICGC	LRKKLKGIN	DEG_APCC_DBOX_1	926:934	Mutation altering degron motif	0.8634
p.R927W	DO7776	COAD	ICGC	LRKKLKGIN	DEG_APCC_DBOX_1	926:934	Mutation altering degron motif	0.8634
p.G932S	TCGA-DA-A3F8	SKCM	TCGA	LRKKLKGIN	DEG_APCC_DBOX_1	926:934	Mutation altering degron motif	0.5882
p.G932S	DO37418	SKCM	ICGC	LRKKLKGIN	DEG_APCC_DBOX_1	926:934	Mutation altering degron motif	0.5882
p.A917V	TCGA-EE-A3JD	SKCM	TCGA	LRKKLKGIN	DEG_APCC_DBOX_1	926:934	Mutation rewiring degron network	0.0833
p.A917V	DO50299	SKCM	ICGC	LRKKLKGIN	DEG_APCC_DBOX_1	926:934	Mutation rewiring degron network	0.0833
p.M942I	TCGA-Z2-AA3V	SKCM	TCGA	LRKKLKGIN	DEG_APCC_DBOX_1	926:934	Mutation rewiring degron network	0.1111
p.M942I	DO220886	MELA	ICGC	LRKKLKGIN	DEG_APCC_DBOX_1	926:934	Mutation rewiring degron network	0.1111
p.M942I	DO51303	SKCM	ICGC	LRKKLKGIN	DEG_APCC_DBOX_1	926:934	Mutation rewiring degron network	0.1111
p.L930M	DO38404	STAD	ICGC	LRKKLKGIN	DEG_APCC_DBOX_1	926:934	Mutation altering degron motif	0.711
p.E929G	SIDM00260	Gastric Carcinoma	GDSC	LRKKLKGIN	DEG_APCC_DBOX_1	926:934	Mutation altering degron motif	0.7199
p.E929G	SIDM00248	Gastric Carcinoma	GDSC	LRKKLKGIN	DEG_APCC_DBOX_1	926:934	Mutation altering degron motif	0.7199
p.E929G	MKN28	stomach	COSMIC	LRKKLKGIN	DEG_APCC_DBOX_1	926:934	Mutation altering degron motif	0.7199
p.R940Q	SIDM00217	Colorectal Carcinoma	GDSC	LRKKLKGIN	DEG_APCC_DBOX_1	926:934	Mutation rewiring degron network	0.1667
p.R940Q	SNU-1040	large intestine	COSMIC	LRKKLKGIN	DEG_APCC_DBOX_1	926:934	Mutation rewiring degron network	0.1667
p.D943N	SIDM01397	Melanoma	GDSC	LRKKLKGIN	DEG_APCC_DBOX_1	926:934	Mutation substituting flanking lysine	0.1944
p.S942C	ACH-001408	Bladder Cancer	CCLE	LRKKLKGIN	DEG_APCC_DBOX_1	926:934	Mutation rewiring degron network	0.1111
p.Y918H	CTV-1	haematopoietic and lymphoid tissue	COSMIC	LRKKLKGIN	DEG_APCC_DBOX_1	926:934	Mutation blocking phosphorylation signal	0.5556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRANK1

UniProt ID: O15050

Entrez ID: 9881

Protein name: TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRANK1 in