DegronMD

Uniprot ID: O15050

Source protein: TPR and ankyrin repeat-containing protein 1

Source gene: TRANK1

Class: DEG_APCC_DBOX_1

Location: 926:934

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7479

ASA_SCORE: 80.3778

COIL: 0.5358

CONS_SCORE: 0.597

DSS_SCORE: 0.1454

HELIX: 0.3669

FCONS_SCORE: 1.3657

RIG_SCORE: 0.8334

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K935E	TCGA-64-1679	LUAD	TCGA	LRKKLKGIN	DEG_APCC_DBOX_1	0.3056
p.K935E	DO26200	LUAD	ICGC	LRKKLKGIN	DEG_APCC_DBOX_1	0.3056
p.R927W	TCGA-D5-6928	COAD	TCGA	LRKKLKGIN	DEG_APCC_DBOX_1	0.8634
p.R927W	TCGA-DK-AA77	BLCA	TCGA	LRKKLKGIN	DEG_APCC_DBOX_1	0.8634
p.R927W	DO219014	BLCA	ICGC	LRKKLKGIN	DEG_APCC_DBOX_1	0.8634
p.R927W	DO7776	COAD	ICGC	LRKKLKGIN	DEG_APCC_DBOX_1	0.8634
p.G932S	TCGA-DA-A3F8	SKCM	TCGA	LRKKLKGIN	DEG_APCC_DBOX_1	0.5882
p.G932S	DO37418	SKCM	ICGC	LRKKLKGIN	DEG_APCC_DBOX_1	0.5882
p.A917V	TCGA-EE-A3JD	SKCM	TCGA	LRKKLKGIN	DEG_APCC_DBOX_1	0.0833
p.A917V	DO50299	SKCM	ICGC	LRKKLKGIN	DEG_APCC_DBOX_1	0.0833
p.M942I	TCGA-Z2-AA3V	SKCM	TCGA	LRKKLKGIN	DEG_APCC_DBOX_1	0.1111
p.M942I	DO220886	MELA	ICGC	LRKKLKGIN	DEG_APCC_DBOX_1	0.1111
p.M942I	DO51303	SKCM	ICGC	LRKKLKGIN	DEG_APCC_DBOX_1	0.1111
p.L930M	DO38404	STAD	ICGC	LRKKLKGIN	DEG_APCC_DBOX_1	0.711
p.E929G	SIDM00260	Gastric Carcinoma	GDSC	LRKKLKGIN	DEG_APCC_DBOX_1	0.7199
p.E929G	SIDM00248	Gastric Carcinoma	GDSC	LRKKLKGIN	DEG_APCC_DBOX_1	0.7199
p.E929G	MKN28	stomach	COSMIC	LRKKLKGIN	DEG_APCC_DBOX_1	0.7199
p.R940Q	SIDM00217	Colorectal Carcinoma	GDSC	LRKKLKGIN	DEG_APCC_DBOX_1	0.1667
p.R940Q	SNU-1040	large_intestine	COSMIC	LRKKLKGIN	DEG_APCC_DBOX_1	0.1667
p.D943N	SIDM01397	Melanoma	GDSC	LRKKLKGIN	DEG_APCC_DBOX_1	0.1944
p.S942C	ACH-001408	Bladder Cancer	CCLE	LRKKLKGIN	DEG_APCC_DBOX_1	0.1111
p.Y918H	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	LRKKLKGIN	DEG_APCC_DBOX_1	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15050	TPR and ankyrin repeat-containing protein 1	DEG_APCC_DBOX_1	926:934	LRKKLKGIN	APC,CDC20,FZR1	0.7479	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons