DegronMD - O15067(PFAS)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E628V	TCGA-18-4083	LUSC	TCGA	PPTPLPT	DEG_SCF_FBW7_1	617:623	Mutation rewiring degron network	0.1944
p.D615Y	TCGA-49-AARO	LUAD	TCGA	PPTPLPT	DEG_SCF_FBW7_1	617:623	Mutation rewiring degron network	0.2778
p.R609I	TCGA-EK-A2RC	CESC	TCGA	PPTPLPT	DEG_SCF_FBW7_1	617:623	Mutation rewiring degron network	0.1111
p.R609I	DO49945	CESC	ICGC	PPTPLPT	DEG_SCF_FBW7_1	617:623	Mutation rewiring degron network	0.1111
p.L627M	TCGA-ER-A19T	SKCM	TCGA	PPTPLPT	DEG_SCF_FBW7_1	617:623	Mutation rewiring degron network	0.2222
p.L627M	DO51251	SKCM	ICGC	PPTPLPT	DEG_SCF_FBW7_1	617:623	Mutation rewiring degron network	0.2222
p.L621P	DO229013	COCA	ICGC	PPTPLPT	DEG_SCF_FBW7_1	617:623	Mutation altering degron motif	0.6471
p.L621P	DO229016	COCA	ICGC	PPTPLPT	DEG_SCF_FBW7_1	617:623	Mutation altering degron motif	0.6471
p.L621P	DO229047	LICA	ICGC	PPTPLPT	DEG_SCF_FBW7_1	617:623	Mutation altering degron motif	0.6471
p.L621P	DO230990	LUSC	ICGC	PPTPLPT	DEG_SCF_FBW7_1	617:623	Mutation altering degron motif	0.6471
p.L621P	DO231075	LUSC	ICGC	PPTPLPT	DEG_SCF_FBW7_1	617:623	Mutation altering degron motif	0.6471
p.L621P	DO231007	LUSC	ICGC	PPTPLPT	DEG_SCF_FBW7_1	617:623	Mutation altering degron motif	0.6471
p.V630M	DO234462	ESAD	ICGC	PPTPLPT	DEG_SCF_FBW7_1	617:623	Mutation rewiring degron network	0.1389
p.E613D	DO229008	LICA	ICGC	PPTPLPT	DEG_SCF_FBW7_1	617:623	Mutation rewiring degron network	0.2222
p.P624A	DO23136	LINC	ICGC	PPTPLPT	DEG_SCF_FBW7_1	617:623	Mutation rewiring degron network	0.3056
p.S629F	DO230950	LUSC	ICGC	PPTPLPT	DEG_SCF_FBW7_1	617:623	Mutation rewiring degron network	0.1667
p.S629F	DO224638	LUSC	ICGC	PPTPLPT	DEG_SCF_FBW7_1	617:623	Mutation rewiring degron network	0.1667
p.S629F	DO220862	MELA	ICGC	PPTPLPT	DEG_SCF_FBW7_1	617:623	Mutation rewiring degron network	0.1667
p.S629F	DO42280	UCEC	ICGC	PPTPLPT	DEG_SCF_FBW7_1	617:623	Mutation rewiring degron network	0.1667
p.A616V	DO232855	NACA	ICGC	PPTPLPT	DEG_SCF_FBW7_1	617:623	Mutation rewiring degron network	0.3056
p.R614Q	DO220269	SARC	ICGC	PPTPLPT	DEG_SCF_FBW7_1	617:623	Mutation rewiring degron network	0.25
p.A616T	SIDM00039	Ovarian Carcinoma	GDSC	PPTPLPT	DEG_SCF_FBW7_1	617:623	Mutation rewiring degron network	0.3056
p.P622S	ACH-000999	Colon/Colorectal Cancer	CCLE	PPTPLPT	DEG_SCF_FBW7_1	617:623	Mutation altering degron motif	0.5641
p.E628Q	ACH-001210	Rhabdoid	CCLE	PPTPLPT	DEG_SCF_FBW7_1	617:623	Mutation rewiring degron network	0.1944

Kaplan plot for PFAS in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PFAS

UniProt ID: O15067

Entrez ID: 5198

Protein name: Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) (Formylglycinamide ribotide amidotransferase) (Phosphoribosylformylglycineamide amidotransferase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PFAS in