DegronMD

Uniprot ID: O15067

Source protein: Phosphoribosylformylglycinamidine synthase

Source gene: PFAS

Class: DEG_SCF_FBW7_1

Location: 617:623

E3 ligase: FBXW7

DEGRON score: 0.962

ASA_SCORE: 79.6857

COIL: 0.9426

CONS_SCORE: 0.1962

DSS_SCORE: 0.5754

HELIX: 0.0097

FCONS_SCORE: 0.5842

RIG_SCORE: 0.6519

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E628V	TCGA-18-4083	LUSC	TCGA	PPTPLPT	DEG_SCF_FBW7_1	0.1944
p.D615Y	TCGA-49-AARO	LUAD	TCGA	PPTPLPT	DEG_SCF_FBW7_1	0.2778
p.R609I	TCGA-EK-A2RC	CESC	TCGA	PPTPLPT	DEG_SCF_FBW7_1	0.1111
p.R609I	DO49945	CESC	ICGC	PPTPLPT	DEG_SCF_FBW7_1	0.1111
p.L627M	TCGA-ER-A19T	SKCM	TCGA	PPTPLPT	DEG_SCF_FBW7_1	0.2222
p.L627M	DO51251	SKCM	ICGC	PPTPLPT	DEG_SCF_FBW7_1	0.2222
p.L621P	DO229013	COCA	ICGC	PPTPLPT	DEG_SCF_FBW7_1	0.6471
p.L621P	DO229016	COCA	ICGC	PPTPLPT	DEG_SCF_FBW7_1	0.6471
p.L621P	DO229047	LICA	ICGC	PPTPLPT	DEG_SCF_FBW7_1	0.6471
p.L621P	DO230990	LUSC	ICGC	PPTPLPT	DEG_SCF_FBW7_1	0.6471
p.L621P	DO231075	LUSC	ICGC	PPTPLPT	DEG_SCF_FBW7_1	0.6471
p.L621P	DO231007	LUSC	ICGC	PPTPLPT	DEG_SCF_FBW7_1	0.6471
p.V630M	DO234462	ESAD	ICGC	PPTPLPT	DEG_SCF_FBW7_1	0.1389
p.E613D	DO229008	LICA	ICGC	PPTPLPT	DEG_SCF_FBW7_1	0.2222
p.P624A	DO23136	LINC	ICGC	PPTPLPT	DEG_SCF_FBW7_1	0.3056
p.S629F	DO230950	LUSC	ICGC	PPTPLPT	DEG_SCF_FBW7_1	0.1667
p.S629F	DO224638	LUSC	ICGC	PPTPLPT	DEG_SCF_FBW7_1	0.1667
p.S629F	DO220862	MELA	ICGC	PPTPLPT	DEG_SCF_FBW7_1	0.1667
p.S629F	DO42280	UCEC	ICGC	PPTPLPT	DEG_SCF_FBW7_1	0.1667
p.A616V	DO232855	NACA	ICGC	PPTPLPT	DEG_SCF_FBW7_1	0.3056
p.R614Q	DO220269	SARC	ICGC	PPTPLPT	DEG_SCF_FBW7_1	0.25
p.A616T	SIDM00039	Ovarian Carcinoma	GDSC	PPTPLPT	DEG_SCF_FBW7_1	0.3056
p.P622S	ACH-000999	Colon/Colorectal Cancer	CCLE	PPTPLPT	DEG_SCF_FBW7_1	0.5641
p.E628Q	ACH-001210	Rhabdoid	CCLE	PPTPLPT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15067	Phosphoribosylformylglycinamidine synthase	DEG_SCF_FBW7_1	617:623	PPTPLPT	FBXW7	0.962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons