DegronMD - O15090(ZNF536)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1150L	TCGA-21-1070	LUSC	TCGA	PETTS	DEG_SPOP_SBC_1	1150:1154	Mutation altering degron motif	0.7582
p.P1150L	TCGA-EB-A431	SKCM	TCGA	PETTS	DEG_SPOP_SBC_1	1150:1154	Mutation altering degron motif	0.7582
p.P1150L	DO27088	LUSC	ICGC	PETTS	DEG_SPOP_SBC_1	1150:1154	Mutation altering degron motif	0.7582
p.P1150L	DO37671	SKCM	ICGC	PETTS	DEG_SPOP_SBC_1	1150:1154	Mutation altering degron motif	0.7582
p.S1154I	TCGA-43-6771	LUSC	TCGA	PETTS	DEG_SPOP_SBC_1	1150:1154	Mutation altering degron motif	0.7341
p.S1154I	DO26443	LUSC	ICGC	PETTS	DEG_SPOP_SBC_1	1150:1154	Mutation altering degron motif	0.7341
p.N1156K	TCGA-52-7812	LUSC	TCGA	PETTS	DEG_SPOP_SBC_1	1150:1154	Mutation rewiring degron network	0.2778
p.N1156K	DO27067	LUSC	ICGC	PETTS	DEG_SPOP_SBC_1	1150:1154	Mutation rewiring degron network	0.2778
p.S1162F	TCGA-85-A4CL	LUSC	TCGA	PETTS	DEG_SPOP_SBC_1	1150:1154	Mutation rewiring degron network	0.1111
p.S1162F	DO45454	LUSC	ICGC	PETTS	DEG_SPOP_SBC_1	1150:1154	Mutation rewiring degron network	0.1111
p.V1145D	TCGA-AD-6548	COAD	TCGA	PETTS	DEG_SPOP_SBC_1	1150:1154	Mutation rewiring degron network	0.1944
p.V1145D	DO9586	COAD	ICGC	PETTS	DEG_SPOP_SBC_1	1150:1154	Mutation rewiring degron network	0.1944
p.E1143K	TCGA-B6-A0RQ	BRCA	TCGA	PETTS	DEG_SPOP_SBC_1	1150:1154	Mutation rewiring degron network	0.1389
p.E1143K	DO5535	BRCA	ICGC	PETTS	DEG_SPOP_SBC_1	1150:1154	Mutation rewiring degron network	0.1389
p.S1141C	TCGA-CR-7371	HNSC	TCGA	PETTS	DEG_SPOP_SBC_1	1150:1154	Mutation blocking phosphorylation signal	0.5278
p.S1141C	DO15454	HNSC	ICGC	PETTS	DEG_SPOP_SBC_1	1150:1154	Mutation blocking phosphorylation signal	0.5278
p.T1152I	TCGA-EE-A2M5	SKCM	TCGA	PETTS	DEG_SPOP_SBC_1	1150:1154	Mutation altering degron motif	0.7078
p.T1152I	DO222423	MELA	ICGC	PETTS	DEG_SPOP_SBC_1	1150:1154	Mutation altering degron motif	0.7078
p.T1152I	DO37425	SKCM	ICGC	PETTS	DEG_SPOP_SBC_1	1150:1154	Mutation altering degron motif	0.7078
p.H1140N	TCGA-EE-A2M7	SKCM	TCGA	PETTS	DEG_SPOP_SBC_1	1150:1154	Mutation rewiring degron network	0.0556
p.H1140N	DO37847	SKCM	ICGC	PETTS	DEG_SPOP_SBC_1	1150:1154	Mutation rewiring degron network	0.0556
p.P1146S	TCGA-FW-A3R5	SKCM	TCGA	PETTS	DEG_SPOP_SBC_1	1150:1154	Mutation rewiring degron network	0.2222
p.P1146S	DO37406	SKCM	ICGC	PETTS	DEG_SPOP_SBC_1	1150:1154	Mutation rewiring degron network	0.2222
p.E1151K	DO222891	COCA	ICGC	PETTS	DEG_SPOP_SBC_1	1150:1154	Mutation altering degron motif	0.591
p.D1160N	DO222731	MELA	ICGC	PETTS	DEG_SPOP_SBC_1	1150:1154	Mutation rewiring degron network	0.1667
p.D1144N	DO222843	MELA	ICGC	PETTS	DEG_SPOP_SBC_1	1150:1154	Mutation rewiring degron network	0.1667
p.T1153M	SIDM00074	Burkitt's Lymphoma	GDSC	PETTS	DEG_SPOP_SBC_1	1150:1154	Mutation altering degron motif	0.7423
p.T1153M	ACH-000402	Lymphoma	CCLE	PETTS	DEG_SPOP_SBC_1	1150:1154	Mutation altering degron motif	0.7423
p.T1153M	BL-70	haematopoietic and lymphoid tissue	COSMIC	PETTS	DEG_SPOP_SBC_1	1150:1154	Mutation altering degron motif	0.7423

Kaplan plot for ZNF536 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF536

UniProt ID: O15090

Entrez ID: 9745

Protein name: Zinc finger protein 536

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF536 in