DegronMD

Uniprot ID: O15090

Source protein: Zinc finger protein 536

Source gene: ZNF536

Class: DEG_SPOP_SBC_1

Location: 1150:1154

E3 ligase: SPOP

DEGRON score: 0.9671

ASA_SCORE: 80.58

COIL: 0.8754

CONS_SCORE: 0.4128

DSS_SCORE: 0.6883

HELIX: 0.03

FCONS_SCORE: 0.8589

RIG_SCORE: 0.6973

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1150L	TCGA-21-1070	LUSC	TCGA	PETTS	DEG_SPOP_SBC_1	0.7582
p.P1150L	TCGA-EB-A431	SKCM	TCGA	PETTS	DEG_SPOP_SBC_1	0.7582
p.P1150L	DO27088	LUSC	ICGC	PETTS	DEG_SPOP_SBC_1	0.7582
p.P1150L	DO37671	SKCM	ICGC	PETTS	DEG_SPOP_SBC_1	0.7582
p.S1154I	TCGA-43-6771	LUSC	TCGA	PETTS	DEG_SPOP_SBC_1	0.7341
p.S1154I	DO26443	LUSC	ICGC	PETTS	DEG_SPOP_SBC_1	0.7341
p.N1156K	TCGA-52-7812	LUSC	TCGA	PETTS	DEG_SPOP_SBC_1	0.2778
p.N1156K	DO27067	LUSC	ICGC	PETTS	DEG_SPOP_SBC_1	0.2778
p.S1162F	TCGA-85-A4CL	LUSC	TCGA	PETTS	DEG_SPOP_SBC_1	0.1111
p.S1162F	DO45454	LUSC	ICGC	PETTS	DEG_SPOP_SBC_1	0.1111
p.V1145D	TCGA-AD-6548	COAD	TCGA	PETTS	DEG_SPOP_SBC_1	0.1944
p.V1145D	DO9586	COAD	ICGC	PETTS	DEG_SPOP_SBC_1	0.1944
p.E1143K	TCGA-B6-A0RQ	BRCA	TCGA	PETTS	DEG_SPOP_SBC_1	0.1389
p.E1143K	DO5535	BRCA	ICGC	PETTS	DEG_SPOP_SBC_1	0.1389
p.S1141C	TCGA-CR-7371	HNSC	TCGA	PETTS	DEG_SPOP_SBC_1	0.5278
p.S1141C	DO15454	HNSC	ICGC	PETTS	DEG_SPOP_SBC_1	0.5278
p.T1152I	TCGA-EE-A2M5	SKCM	TCGA	PETTS	DEG_SPOP_SBC_1	0.7078
p.T1152I	DO222423	MELA	ICGC	PETTS	DEG_SPOP_SBC_1	0.7078
p.T1152I	DO37425	SKCM	ICGC	PETTS	DEG_SPOP_SBC_1	0.7078
p.H1140N	TCGA-EE-A2M7	SKCM	TCGA	PETTS	DEG_SPOP_SBC_1	0.0556
p.H1140N	DO37847	SKCM	ICGC	PETTS	DEG_SPOP_SBC_1	0.0556
p.P1146S	TCGA-FW-A3R5	SKCM	TCGA	PETTS	DEG_SPOP_SBC_1	0.2222
p.P1146S	DO37406	SKCM	ICGC	PETTS	DEG_SPOP_SBC_1	0.2222
p.E1151K	DO222891	COCA	ICGC	PETTS	DEG_SPOP_SBC_1	0.591
p.D1160N	DO222731	MELA	ICGC	PETTS	DEG_SPOP_SBC_1	0.1667
p.D1144N	DO222843	MELA	ICGC	PETTS	DEG_SPOP_SBC_1	0.1667
p.T1153M	SIDM00074	Burkitt's Lymphoma	GDSC	PETTS	DEG_SPOP_SBC_1	0.7423
p.T1153M	ACH-000402	Lymphoma	CCLE	PETTS	DEG_SPOP_SBC_1	0.7423
p.T1153M	BL-70	haematopoietic_and_lymphoid_tissue	COSMIC	PETTS	DEG_SPOP_SBC_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7E2V4	Zinc finger SWIM domain-containing protein 8	DEG_SPOP_SBC_1	1149:1153	PETTS	SPOP	0.9985	More...
P52292	Importin subunit alpha-1	DEG_SPOP_SBC_1	508:512	PETTS	SPOP	0.6747	More...
Q12947	Forkhead box protein F2	DEG_SPOP_SBC_1	42:46	PETTS	SPOP	0.9367	More...
Q7Z6L1	Tectonin beta-propeller repeat-containing protein 1	DEG_SPOP_SBC_1	507:511	PETTS	SPOP	0.9805	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9484:9488	PETTS	SPOP	0.881	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10535:10539	PETTS	SPOP	0.8354	More...
Q96FE7	Phosphoinositide-3-kinase-interacting protein 1	DEG_SPOP_SBC_1	102:106	PETTS	SPOP	0.939	More...
Q9UKN7	Unconventional myosin-XV	DEG_SPOP_SBC_1	2549:2553	PETTS	SPOP	0.9909	More...
O15090	Zinc finger protein 536	DEG_SPOP_SBC_1	1150:1154	PETTS	SPOP	0.9671	More...
Q8TD55	Pleckstrin homology domain-containing family O member 2	DEG_SPOP_SBC_1	213:217	PETTS	SPOP	0.9242	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PETTS

Degron related mutations and impact score

Drug responses associated with ZNF536 mutations

All proteins holding degron of PETTS