DegronMD

Uniprot ID: Q7Z6L1

Source protein: Tectonin beta-propeller repeat-containing protein 1

Source gene: TECPR1

Class: DEG_SPOP_SBC_1

Location: 507:511

E3 ligase: SPOP

DEGRON score: 0.9805

ASA_SCORE: 78.58

COIL: 0.7414

CONS_SCORE: 0.3315

DSS_SCORE: 0.3449

HELIX: 0.1428

FCONS_SCORE: 0.9976

RIG_SCORE: 0.7168

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G521C	TCGA-69-7980	LUAD	TCGA	PETTS	DEG_SPOP_SBC_1	0.0556
p.S502L	TCGA-EE-A183	SKCM	TCGA	PETTS	DEG_SPOP_SBC_1	0.1944
p.S502L	TCGA-FD-A6TA	BLCA	TCGA	PETTS	DEG_SPOP_SBC_1	0.1944
p.L515V	TCGA-IR-A3LA	CESC	TCGA	PETTS	DEG_SPOP_SBC_1	0.2222
p.S502W	TCGA-Z6-AAPN	ESCA	TCGA	PETTS	DEG_SPOP_SBC_1	0.1944
p.Q511H	DO474	BLCA	ICGC	PETTS	DEG_SPOP_SBC_1	0.7582
p.P502L	DO12370	GBM	ICGC	PETTS	DEG_SPOP_SBC_1	0.1944
p.T520I	DO11854	GBM	ICGC	PETTS	DEG_SPOP_SBC_1	0.0833
p.R509S	DO228813	LICA	ICGC	PETTS	DEG_SPOP_SBC_1	0.7427
p.R509S	DO229245	THCA	ICGC	PETTS	DEG_SPOP_SBC_1	0.7427
p.T517K	DO228941	LICA	ICGC	PETTS	DEG_SPOP_SBC_1	0.1667
p.T517K	DO229027	LICA	ICGC	PETTS	DEG_SPOP_SBC_1	0.1667
p.S497Y	DO229024	LICA	ICGC	PETTS	DEG_SPOP_SBC_1	0.1667
p.T501M	DO42256	UCEC	ICGC	PETTS	DEG_SPOP_SBC_1	0.1667
p.A506T	DO41361	UCEC	ICGC	PETTS	DEG_SPOP_SBC_1	0.3056
p.E508K	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	PETTS	DEG_SPOP_SBC_1	0.591
p.E508K	ACH-000855	Esophageal Cancer	CCLE	PETTS	DEG_SPOP_SBC_1	0.591
p.E508K	KYSE-150	oesophagus	COSMIC	PETTS	DEG_SPOP_SBC_1	0.591
p.A504T	ACH-000829	Myeloma	CCLE	PETTS	DEG_SPOP_SBC_1	0.25
p.G505D	ACH-001864	Bile Duct Cancer	CCLE	PETTS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7E2V4	Zinc finger SWIM domain-containing protein 8	DEG_SPOP_SBC_1	1149:1153	PETTS	SPOP	0.9985	More...
P52292	Importin subunit alpha-1	DEG_SPOP_SBC_1	508:512	PETTS	SPOP	0.6747	More...
Q12947	Forkhead box protein F2	DEG_SPOP_SBC_1	42:46	PETTS	SPOP	0.9367	More...
Q7Z6L1	Tectonin beta-propeller repeat-containing protein 1	DEG_SPOP_SBC_1	507:511	PETTS	SPOP	0.9805	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9484:9488	PETTS	SPOP	0.881	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10535:10539	PETTS	SPOP	0.8354	More...
Q96FE7	Phosphoinositide-3-kinase-interacting protein 1	DEG_SPOP_SBC_1	102:106	PETTS	SPOP	0.939	More...
Q9UKN7	Unconventional myosin-XV	DEG_SPOP_SBC_1	2549:2553	PETTS	SPOP	0.9909	More...
O15090	Zinc finger protein 536	DEG_SPOP_SBC_1	1150:1154	PETTS	SPOP	0.9671	More...
Q8TD55	Pleckstrin homology domain-containing family O member 2	DEG_SPOP_SBC_1	213:217	PETTS	SPOP	0.9242	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons