DegronMD

Uniprot ID: P52292

Source protein: Importin subunit alpha-1

Source gene: KPNA2

Class: DEG_SPOP_SBC_1

Location: 508:512

E3 ligase: SPOP

DEGRON score: 0.6747

ASA_SCORE: 83.4

COIL: 0.8366

CONS_SCORE: 0.3345

DSS_SCORE: 0.5945

HELIX: 0.0788

FCONS_SCORE: 0.9938

RIG_SCORE: 0.7504

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S512C	TCGA-BT-A20J	BLCA	TCGA	PETTS	DEG_SPOP_SBC_1	0.8652
p.S512C	DO457	BLCA	ICGC	PETTS	DEG_SPOP_SBC_1	0.8652
p.Q518K	TCGA-BT-A20J	BLCA	TCGA	PETTS	DEG_SPOP_SBC_1	0.1667
p.Q518K	DO457	BLCA	ICGC	PETTS	DEG_SPOP_SBC_1	0.1667
p.E499K	TCGA-CR-6481	HNSC	TCGA	PETTS	DEG_SPOP_SBC_1	0.0833
p.V506I	DO225004	BRCA	ICGC	PETTS	DEG_SPOP_SBC_1	0.2778
p.V506I	SIDM00967	Ovarian Carcinoma	GDSC	PETTS	DEG_SPOP_SBC_1	0.2778
p.V506I	SIDM00454	Rhabdomyosarcoma	GDSC	PETTS	DEG_SPOP_SBC_1	0.2778
p.V506I	SIDM00690	Head and Neck Carcinoma	GDSC	PETTS	DEG_SPOP_SBC_1	0.2778
p.V506I	SIDM00971	Breast Carcinoma	GDSC	PETTS	DEG_SPOP_SBC_1	0.2778
p.V506I	SIDM01752	Pancreatic Carcinoma	GDSC	PETTS	DEG_SPOP_SBC_1	0.2778
p.Y515N	DO234285	ESAD	ICGC	PETTS	DEG_SPOP_SBC_1	0.25
p.N505D	DO233706	GACA	ICGC	PETTS	DEG_SPOP_SBC_1	0.25
p.G514V	DO229008	LICA	ICGC	PETTS	DEG_SPOP_SBC_1	0.2778
p.E509K	SIDM00570	Gastric Carcinoma	GDSC	PETTS	DEG_SPOP_SBC_1	0.591
p.E509K	ACH-000674	Gastric Cancer	CCLE	PETTS	DEG_SPOP_SBC_1	0.591
p.E509K	NUGC-4	stomach	COSMIC	PETTS	DEG_SPOP_SBC_1	0.591

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7E2V4	Zinc finger SWIM domain-containing protein 8	DEG_SPOP_SBC_1	1149:1153	PETTS	SPOP	0.9985	More...
P52292	Importin subunit alpha-1	DEG_SPOP_SBC_1	508:512	PETTS	SPOP	0.6747	More...
Q12947	Forkhead box protein F2	DEG_SPOP_SBC_1	42:46	PETTS	SPOP	0.9367	More...
Q7Z6L1	Tectonin beta-propeller repeat-containing protein 1	DEG_SPOP_SBC_1	507:511	PETTS	SPOP	0.9805	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9484:9488	PETTS	SPOP	0.881	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10535:10539	PETTS	SPOP	0.8354	More...
Q96FE7	Phosphoinositide-3-kinase-interacting protein 1	DEG_SPOP_SBC_1	102:106	PETTS	SPOP	0.939	More...
Q9UKN7	Unconventional myosin-XV	DEG_SPOP_SBC_1	2549:2553	PETTS	SPOP	0.9909	More...
O15090	Zinc finger protein 536	DEG_SPOP_SBC_1	1150:1154	PETTS	SPOP	0.9671	More...
Q8TD55	Pleckstrin homology domain-containing family O member 2	DEG_SPOP_SBC_1	213:217	PETTS	SPOP	0.9242	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons