DegronMD

Uniprot ID: Q96FE7

Source protein: Phosphoinositide-3-kinase-interacting protein 1

Source gene: PIK3IP1

Class: DEG_SPOP_SBC_1

Location: 102:106

E3 ligase: SPOP

DEGRON score: 0.939

ASA_SCORE: 73.64

COIL: 0.7848

CONS_SCORE: 0.4259

DSS_SCORE: 0.4438

HELIX: 0.1432

FCONS_SCORE: 0.9506

RIG_SCORE: 0.7496

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q107H	TCGA-A5-A0G1	UCEC	TCGA	PETTS	DEG_SPOP_SBC_1	0.3056
p.A111T	TCGA-BS-A0UV	UCEC	TCGA	PETTS	DEG_SPOP_SBC_1	0.1944
p.E115K	TCGA-VS-A9UA	CESC	TCGA	PETTS	DEG_SPOP_SBC_1	0.0833
p.G106A	DO219052	BLCA	ICGC	PETTS	DEG_SPOP_SBC_1	0.754
p.G106E	DO2281	BRCA	ICGC	PETTS	DEG_SPOP_SBC_1	0.7199
p.A104V	DO8151	COAD	ICGC	PETTS	DEG_SPOP_SBC_1	0.6936
p.I105M	DO233189	GACA	ICGC	PETTS	DEG_SPOP_SBC_1	0.7618
p.S114Y	DO37831	SKCM	ICGC	PETTS	DEG_SPOP_SBC_1	0.1111
p.G95C	DO37421	SKCM	ICGC	PETTS	DEG_SPOP_SBC_1	0.1389
p.G108D	DO41752	UCEC	ICGC	PETTS	DEG_SPOP_SBC_1	0.2778
p.R94P	SIDM00881	Breast Carcinoma	GDSC	PETTS	DEG_SPOP_SBC_1	0.1111
p.R94P	ACH-000352	Breast Cancer	CCLE	PETTS	DEG_SPOP_SBC_1	0.1111
p.R94P	HCC1428	breast	COSMIC	PETTS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7E2V4	Zinc finger SWIM domain-containing protein 8	DEG_SPOP_SBC_1	1149:1153	PETTS	SPOP	0.9985	More...
P52292	Importin subunit alpha-1	DEG_SPOP_SBC_1	508:512	PETTS	SPOP	0.6747	More...
Q12947	Forkhead box protein F2	DEG_SPOP_SBC_1	42:46	PETTS	SPOP	0.9367	More...
Q7Z6L1	Tectonin beta-propeller repeat-containing protein 1	DEG_SPOP_SBC_1	507:511	PETTS	SPOP	0.9805	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9484:9488	PETTS	SPOP	0.881	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10535:10539	PETTS	SPOP	0.8354	More...
Q96FE7	Phosphoinositide-3-kinase-interacting protein 1	DEG_SPOP_SBC_1	102:106	PETTS	SPOP	0.939	More...
Q9UKN7	Unconventional myosin-XV	DEG_SPOP_SBC_1	2549:2553	PETTS	SPOP	0.9909	More...
O15090	Zinc finger protein 536	DEG_SPOP_SBC_1	1150:1154	PETTS	SPOP	0.9671	More...
Q8TD55	Pleckstrin homology domain-containing family O member 2	DEG_SPOP_SBC_1	213:217	PETTS	SPOP	0.9242	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons