DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 10535:10539

E3 ligase: SPOP

DEGRON score: 0.8354

ASA_SCORE: 88.88

COIL: 0.7792

CONS_SCORE: 0

DSS_SCORE: 0.4253

HELIX: 0.0258

FCONS_SCORE: 0

RIG_SCORE: 0.7502

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T10537M	TCGA-AO-A124	BRCA	TCGA	PETTS	DEG_SPOP_SBC_1	0.7423
p.T10537M	DO1287	BRCA	ICGC	PETTS	DEG_SPOP_SBC_1	0.7423
p.S10539P	TCGA-DK-A6AW	BLCA	TCGA	PETTS	DEG_SPOP_SBC_1	0.6752
p.S10539P	DO48566	BLCA	ICGC	PETTS	DEG_SPOP_SBC_1	0.6752
p.V10530A	TCGA-E6-A1LX	UCEC	TCGA	PETTS	DEG_SPOP_SBC_1	0.1944
p.V10530A	DO41020	UCEC	ICGC	PETTS	DEG_SPOP_SBC_1	0.1944
p.F10531S	DO220857	MELA	ICGC	PETTS	DEG_SPOP_SBC_1	0.2222
p.G10546K	DO222731	MELA	ICGC	PETTS	DEG_SPOP_SBC_1	0.1389
p.G10546R	DO222868	MELA	ICGC	PETTS	DEG_SPOP_SBC_1	0.1389
p.S10540L	SIDM00871	Non-Cancerous	GDSC	PETTS	DEG_SPOP_SBC_1	0.3056
p.S10540L	SIDM00872	Breast Carcinoma	GDSC	PETTS	DEG_SPOP_SBC_1	0.3056
p.S10540L	ACH-000859	Breast Cancer	CCLE	PETTS	DEG_SPOP_SBC_1	0.3056
p.S10540L	ACH-002384	Non-Cancerous	CCLE	PETTS	DEG_SPOP_SBC_1	0.3056
p.A10542S	SIDM00743	Non-Small Cell Lung Carcinoma	GDSC	PETTS	DEG_SPOP_SBC_1	0.25
p.A10542S	ACH-000448	Lung Cancer	CCLE	PETTS	DEG_SPOP_SBC_1	0.25
p.A10542S	NCI-H1666	lung	COSMIC	PETTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7E2V4	Zinc finger SWIM domain-containing protein 8	DEG_SPOP_SBC_1	1149:1153	PETTS	SPOP	0.9985	More...
P52292	Importin subunit alpha-1	DEG_SPOP_SBC_1	508:512	PETTS	SPOP	0.6747	More...
Q12947	Forkhead box protein F2	DEG_SPOP_SBC_1	42:46	PETTS	SPOP	0.9367	More...
Q7Z6L1	Tectonin beta-propeller repeat-containing protein 1	DEG_SPOP_SBC_1	507:511	PETTS	SPOP	0.9805	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9484:9488	PETTS	SPOP	0.881	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10535:10539	PETTS	SPOP	0.8354	More...
Q96FE7	Phosphoinositide-3-kinase-interacting protein 1	DEG_SPOP_SBC_1	102:106	PETTS	SPOP	0.939	More...
Q9UKN7	Unconventional myosin-XV	DEG_SPOP_SBC_1	2549:2553	PETTS	SPOP	0.9909	More...
O15090	Zinc finger protein 536	DEG_SPOP_SBC_1	1150:1154	PETTS	SPOP	0.9671	More...
Q8TD55	Pleckstrin homology domain-containing family O member 2	DEG_SPOP_SBC_1	213:217	PETTS	SPOP	0.9242	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons