DegronMD

Uniprot ID: Q8TD55

Source protein: Pleckstrin homology domain-containing family O member 2

Source gene: PLEKHO2

Class: DEG_SPOP_SBC_1

Location: 213:217

E3 ligase: SPOP

DEGRON score: 0.9242

ASA_SCORE: 96.76

COIL: 0.9464

CONS_SCORE: 0.4463

DSS_SCORE: 0.7652

HELIX: 0.0182

FCONS_SCORE: 0.9759

RIG_SCORE: 0.6035

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S217G	TCGA-AX-A2HC	UCEC	TCGA	PETTS	DEG_SPOP_SBC_1	0.6993
p.S217G	DO41572	UCEC	ICGC	PETTS	DEG_SPOP_SBC_1	0.6993
p.P206S	TCGA-BF-AAP2	SKCM	TCGA	PETTS	DEG_SPOP_SBC_1	0.1389
p.P206S	DO219466	SKCM	ICGC	PETTS	DEG_SPOP_SBC_1	0.1389
p.P218S	TCGA-FW-A3R5	SKCM	TCGA	PETTS	DEG_SPOP_SBC_1	0.3056
p.P218S	DO37406	SKCM	ICGC	PETTS	DEG_SPOP_SBC_1	0.3056
p.P218L	TCGA-FW-A3R5	SKCM	TCGA	PETTS	DEG_SPOP_SBC_1	0.3056
p.P218L	DO37406	SKCM	ICGC	PETTS	DEG_SPOP_SBC_1	0.3056
p.P209T	SIDM02031	Esophageal Carcinoma	GDSC	PETTS	DEG_SPOP_SBC_1	0.2222
p.D220G	SIDM00217	Colorectal Carcinoma	GDSC	PETTS	DEG_SPOP_SBC_1	0.25
p.D220G	ACH-000999	Colon/Colorectal Cancer	CCLE	PETTS	DEG_SPOP_SBC_1	0.25
p.D220G	SNU-1040	large_intestine	COSMIC	PETTS	DEG_SPOP_SBC_1	0.25
p.N213I	KARPAS-620	haematopoietic_and_lymphoid_tissue	COSMIC	PETTS	DEG_SPOP_SBC_1	0.728

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7E2V4	Zinc finger SWIM domain-containing protein 8	DEG_SPOP_SBC_1	1149:1153	PETTS	SPOP	0.9985	More...
P52292	Importin subunit alpha-1	DEG_SPOP_SBC_1	508:512	PETTS	SPOP	0.6747	More...
Q12947	Forkhead box protein F2	DEG_SPOP_SBC_1	42:46	PETTS	SPOP	0.9367	More...
Q7Z6L1	Tectonin beta-propeller repeat-containing protein 1	DEG_SPOP_SBC_1	507:511	PETTS	SPOP	0.9805	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9484:9488	PETTS	SPOP	0.881	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10535:10539	PETTS	SPOP	0.8354	More...
Q96FE7	Phosphoinositide-3-kinase-interacting protein 1	DEG_SPOP_SBC_1	102:106	PETTS	SPOP	0.939	More...
Q9UKN7	Unconventional myosin-XV	DEG_SPOP_SBC_1	2549:2553	PETTS	SPOP	0.9909	More...
O15090	Zinc finger protein 536	DEG_SPOP_SBC_1	1150:1154	PETTS	SPOP	0.9671	More...
Q8TD55	Pleckstrin homology domain-containing family O member 2	DEG_SPOP_SBC_1	213:217	PETTS	SPOP	0.9242	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons