DegronMD

Uniprot ID: Q9UKN7

Source protein: Unconventional myosin-XV

Source gene: MYO15A

Class: DEG_SPOP_SBC_1

Location: 2549:2553

E3 ligase: SPOP

DEGRON score: 0.9909

ASA_SCORE: 97.56

COIL: 0.9564

CONS_SCORE: 0.3618

DSS_SCORE: 0.6421

HELIX: 0.0156

FCONS_SCORE: 1.1658

RIG_SCORE: 0.5842

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y2561C	TCGA-51-4080	LUSC	TCGA	PETTS	DEG_SPOP_SBC_1	0.1111
p.Y2561C	DO26441	LUSC	ICGC	PETTS	DEG_SPOP_SBC_1	0.1111
p.S2553A	TCGA-BR-8589	STAD	TCGA	PETTS	DEG_SPOP_SBC_1	0.7588
p.S2553A	DO47813	STAD	ICGC	PETTS	DEG_SPOP_SBC_1	0.7588
p.R2560Q	TCGA-D1-A17F	UCEC	TCGA	PETTS	DEG_SPOP_SBC_1	0.1389
p.R2560Q	DO222469	ESCA	ICGC	PETTS	DEG_SPOP_SBC_1	0.1389
p.R2560Q	DO43362	UCEC	ICGC	PETTS	DEG_SPOP_SBC_1	0.1389
p.R2560L	TCGA-D9-A148	SKCM	TCGA	PETTS	DEG_SPOP_SBC_1	0.1389
p.R2560L	DO37971	SKCM	ICGC	PETTS	DEG_SPOP_SBC_1	0.1389
p.T2551A	SIDM00118	Colorectal Carcinoma	GDSC	PETTS	DEG_SPOP_SBC_1	0.7139
p.T2551A	ACH-001081	Colon/Colorectal Cancer	CCLE	PETTS	DEG_SPOP_SBC_1	0.7139
p.T2551A	HCC2998	large_intestine	COSMIC	PETTS	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7E2V4	Zinc finger SWIM domain-containing protein 8	DEG_SPOP_SBC_1	1149:1153	PETTS	SPOP	0.9985	More...
P52292	Importin subunit alpha-1	DEG_SPOP_SBC_1	508:512	PETTS	SPOP	0.6747	More...
Q12947	Forkhead box protein F2	DEG_SPOP_SBC_1	42:46	PETTS	SPOP	0.9367	More...
Q7Z6L1	Tectonin beta-propeller repeat-containing protein 1	DEG_SPOP_SBC_1	507:511	PETTS	SPOP	0.9805	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9484:9488	PETTS	SPOP	0.881	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10535:10539	PETTS	SPOP	0.8354	More...
Q96FE7	Phosphoinositide-3-kinase-interacting protein 1	DEG_SPOP_SBC_1	102:106	PETTS	SPOP	0.939	More...
Q9UKN7	Unconventional myosin-XV	DEG_SPOP_SBC_1	2549:2553	PETTS	SPOP	0.9909	More...
O15090	Zinc finger protein 536	DEG_SPOP_SBC_1	1150:1154	PETTS	SPOP	0.9671	More...
Q8TD55	Pleckstrin homology domain-containing family O member 2	DEG_SPOP_SBC_1	213:217	PETTS	SPOP	0.9242	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons