DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 9484:9488

E3 ligase: SPOP

DEGRON score: 0.881

ASA_SCORE: 95.44

COIL: 0.8188

CONS_SCORE: 0

DSS_SCORE: 0.5719

HELIX: 0.0148

FCONS_SCORE: 0

RIG_SCORE: 0.7035

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T9486P	TCGA-BR-6458	STAD	TCGA	PETTS	DEG_SPOP_SBC_1	0.7031
p.T9486P	DO38296	STAD	ICGC	PETTS	DEG_SPOP_SBC_1	0.7031
p.S9481N	DO233955	BPLL	ICGC	PETTS	DEG_SPOP_SBC_1	0.25
p.A9480E	DO229032	LICA	ICGC	PETTS	DEG_SPOP_SBC_1	0.2222
p.A9489T	DO220891	MELA	ICGC	PETTS	DEG_SPOP_SBC_1	0.3056
p.E9485K	SIDM00007	Other Solid Cancers	GDSC	PETTS	DEG_SPOP_SBC_1	0.591
p.E9485K	ACH-001550	Skin Cancer	CCLE	PETTS	DEG_SPOP_SBC_1	0.591
p.E9485K	MCC13	skin	COSMIC	PETTS	DEG_SPOP_SBC_1	0.591

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7E2V4	Zinc finger SWIM domain-containing protein 8	DEG_SPOP_SBC_1	1149:1153	PETTS	SPOP	0.9985	More...
P52292	Importin subunit alpha-1	DEG_SPOP_SBC_1	508:512	PETTS	SPOP	0.6747	More...
Q12947	Forkhead box protein F2	DEG_SPOP_SBC_1	42:46	PETTS	SPOP	0.9367	More...
Q7Z6L1	Tectonin beta-propeller repeat-containing protein 1	DEG_SPOP_SBC_1	507:511	PETTS	SPOP	0.9805	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9484:9488	PETTS	SPOP	0.881	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10535:10539	PETTS	SPOP	0.8354	More...
Q96FE7	Phosphoinositide-3-kinase-interacting protein 1	DEG_SPOP_SBC_1	102:106	PETTS	SPOP	0.939	More...
Q9UKN7	Unconventional myosin-XV	DEG_SPOP_SBC_1	2549:2553	PETTS	SPOP	0.9909	More...
O15090	Zinc finger protein 536	DEG_SPOP_SBC_1	1150:1154	PETTS	SPOP	0.9671	More...
Q8TD55	Pleckstrin homology domain-containing family O member 2	DEG_SPOP_SBC_1	213:217	PETTS	SPOP	0.9242	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons