DegronMD - Q7Z6L1(TECPR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G521C	TCGA-69-7980	LUAD	TCGA	PETTS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.0556
p.S502L	TCGA-EE-A183	SKCM	TCGA	PETTS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.1944
p.S502L	TCGA-FD-A6TA	BLCA	TCGA	PETTS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.1944
p.L515V	TCGA-IR-A3LA	CESC	TCGA	PETTS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.2222
p.S502W	TCGA-Z6-AAPN	ESCA	TCGA	PETTS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.1944
p.Q511H	DO474	BLCA	ICGC	PETTS	DEG_SPOP_SBC_1	507:511	Mutation altering degron motif	0.7582
p.P502L	DO12370	GBM	ICGC	PETTS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.1944
p.T520I	DO11854	GBM	ICGC	PETTS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.0833
p.R509S	DO228813	LICA	ICGC	PETTS	DEG_SPOP_SBC_1	507:511	Mutation altering degron motif	0.7427
p.R509S	DO229245	THCA	ICGC	PETTS	DEG_SPOP_SBC_1	507:511	Mutation altering degron motif	0.7427
p.T517K	DO228941	LICA	ICGC	PETTS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.1667
p.T517K	DO229027	LICA	ICGC	PETTS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.1667
p.S497Y	DO229024	LICA	ICGC	PETTS	DEG_SPOP_SBC_1	507:511	Mutation substituting flanking lysine	0.1667
p.T501M	DO42256	UCEC	ICGC	PETTS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.1667
p.A506T	DO41361	UCEC	ICGC	PETTS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.3056
p.E508K	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	PETTS	DEG_SPOP_SBC_1	507:511	Mutation altering degron motif	0.591
p.E508K	ACH-000855	Esophageal Cancer	CCLE	PETTS	DEG_SPOP_SBC_1	507:511	Mutation altering degron motif	0.591
p.E508K	KYSE-150	oesophagus	COSMIC	PETTS	DEG_SPOP_SBC_1	507:511	Mutation altering degron motif	0.591
p.A504T	ACH-000829	Myeloma	CCLE	PETTS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.25
p.G505D	ACH-001864	Bile Duct Cancer	CCLE	PETTS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.2778

Kaplan plot for TECPR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TECPR1

UniProt ID: Q7Z6L1

Entrez ID: 25851

Protein name: Tectonin beta-propeller repeat-containing protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TECPR1 in