DegronMD - Q9UKN7(MYO15A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A198T	TCGA-06-6699	GBM	TCGA	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.1389
p.A198T	TCGA-X8-AAAR	ESCA	TCGA	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.1389
p.A198T	DO52432	COCA	ICGC	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.1389
p.A198T	DO13893	GBM	ICGC	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.1389
p.D210Y	TCGA-19-4065	GBM	TCGA	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation altering degron motif	0.7325
p.D210Y	DO11591	GBM	ICGC	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation altering degron motif	0.7325
p.V2512M	TCGA-28-1746	GBM	TCGA	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	2521:2534	Mutation rewiring degron network	0.0833
p.V2512M	TCGA-IB-7651	PAAD	TCGA	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	2521:2534	Mutation rewiring degron network	0.0833
p.V2512M	DO13564	GBM	ICGC	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	2521:2534	Mutation rewiring degron network	0.0833
p.V2512M	DO46657	PAAD	ICGC	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	2521:2534	Mutation rewiring degron network	0.0833
p.V2512M	SIDM01617	Endometrial Carcinoma	GDSC	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	2521:2534	Mutation rewiring degron network	0.0833
p.R220S	TCGA-49-6761	LUAD	TCGA	SRKSLYGLE	DEG_APCC_DBOX_1	219:227	Mutation altering degron motif	0.7427
p.R220S	DO24566	LUAD	ICGC	SRKSLYGLE	DEG_APCC_DBOX_1	219:227	Mutation altering degron motif	0.7427
p.Y2561C	TCGA-51-4080	LUSC	TCGA	PETTS	DEG_SPOP_SBC_1	2549:2553	Mutation rewiring degron network	0.1111
p.Y2561C	DO26441	LUSC	ICGC	PETTS	DEG_SPOP_SBC_1	2549:2553	Mutation rewiring degron network	0.1111
p.A2527T	TCGA-AP-A0LM	UCEC	TCGA	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	2521:2534	Mutation altering degron motif	0.6028
p.A2527T	DO43306	UCEC	ICGC	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	2521:2534	Mutation altering degron motif	0.6028
p.T1045A	TCGA-B5-A3FA	UCEC	TCGA	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	1035:1042	Mutation blocking phosphorylation signal	0.6944
p.T1045A	DO52402	UCEC	ICGC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	1035:1042	Mutation blocking phosphorylation signal	0.6944
p.R2515H	TCGA-B5-A3FC	UCEC	TCGA	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	2521:2534	Mutation rewiring degron network	0.1667
p.R2515H	DO41871	UCEC	ICGC	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	2521:2534	Mutation rewiring degron network	0.1667
p.R2515H	SIDM00437	Acute Myeloid Leukemia	GDSC	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	2521:2534	Mutation rewiring degron network	0.1667
p.R2515H	ACH-000362	Leukemia	CCLE	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	2521:2534	Mutation rewiring degron network	0.1667
p.R2515H	MOLM-13	haematopoietic and lymphoid tissue	COSMIC	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	2521:2534	Mutation rewiring degron network	0.1667
p.S2553A	TCGA-BR-8589	STAD	TCGA	PETTS	DEG_SPOP_SBC_1	2549:2553	Mutation altering degron motif	0.7588
p.S2553A	DO47813	STAD	ICGC	PETTS	DEG_SPOP_SBC_1	2549:2553	Mutation altering degron motif	0.7588
p.E211D	TCGA-CK-4951	COAD	TCGA	SRKSLYGLE	DEG_APCC_DBOX_1	219:227	Mutation rewiring degron network	0.1111
p.E211D	TCGA-CK-4951	COAD	TCGA	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.3056
p.E211D	DO10582	COAD	ICGC	SRKSLYGLE	DEG_APCC_DBOX_1	219:227	Mutation rewiring degron network	0.1111
p.E211D	DO10582	COAD	ICGC	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.3056
p.R2560Q	TCGA-D1-A17F	UCEC	TCGA	PETTS	DEG_SPOP_SBC_1	2549:2553	Mutation rewiring degron network	0.1389
p.R2560Q	DO222469	ESCA	ICGC	PETTS	DEG_SPOP_SBC_1	2549:2553	Mutation rewiring degron network	0.1389
p.R2560Q	DO43362	UCEC	ICGC	PETTS	DEG_SPOP_SBC_1	2549:2553	Mutation rewiring degron network	0.1389
p.E201K	TCGA-D3-A8GQ	SKCM	TCGA	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.2222
p.E201K	DO51246	SKCM	ICGC	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.2222
p.E201K	ACH-001456	Colon/Colorectal Cancer	CCLE	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.2222
p.R2560L	TCGA-D9-A148	SKCM	TCGA	PETTS	DEG_SPOP_SBC_1	2549:2553	Mutation rewiring degron network	0.1389
p.R2560L	DO37971	SKCM	ICGC	PETTS	DEG_SPOP_SBC_1	2549:2553	Mutation rewiring degron network	0.1389
p.L226F	TCGA-EL-A3GV	THCA	TCGA	SRKSLYGLE	DEG_APCC_DBOX_1	219:227	Mutation altering degron motif	0.6981
p.L226F	DO39628	THCA	ICGC	SRKSLYGLE	DEG_APCC_DBOX_1	219:227	Mutation altering degron motif	0.6981
p.A2538V	TCGA-HU-A4GN	STAD	TCGA	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	2521:2534	Mutation rewiring degron network	0.2222
p.A2538V	DO47833	STAD	ICGC	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	2521:2534	Mutation rewiring degron network	0.2222
p.D1037G	TCGA-IB-7651	PAAD	TCGA	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	1035:1042	Mutation altering degron motif	0.7198
p.D1037G	DO46657	PAAD	ICGC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	1035:1042	Mutation altering degron motif	0.7198
p.R220C	TCGA-NH-A6GC	COAD	TCGA	SRKSLYGLE	DEG_APCC_DBOX_1	219:227	Mutation altering degron motif	0.8301
p.R220C	DO50093	COAD	ICGC	SRKSLYGLE	DEG_APCC_DBOX_1	219:227	Mutation altering degron motif	0.8301
p.P213S	TCGA-WE-A8K6	SKCM	TCGA	SRKSLYGLE	DEG_APCC_DBOX_1	219:227	Mutation rewiring degron network	0.1667
p.P213S	TCGA-WE-A8K6	SKCM	TCGA	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.25
p.P213S	DO51283	SKCM	ICGC	SRKSLYGLE	DEG_APCC_DBOX_1	219:227	Mutation rewiring degron network	0.1667
p.P213S	DO51283	SKCM	ICGC	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.25
p.D1043N	TCGA-Z2-A8RT	SKCM	TCGA	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	1035:1042	Mutation rewiring degron network	0.3056
p.D1043N	DO51301	SKCM	ICGC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	1035:1042	Mutation rewiring degron network	0.3056
p.G202A	DO223599	BLCA	ICGC	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.25
p.S228F	DO219641	BRCA	ICGC	SRKSLYGLE	DEG_APCC_DBOX_1	219:227	Mutation rewiring degron network	0.3056
p.A203V	DO9010	COAD	ICGC	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.2778
p.L2513I	DO230335	COCA	ICGC	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	2521:2534	Mutation rewiring degron network	0.1111
p.G225R	DO233933	GACA	ICGC	SRKSLYGLE	DEG_APCC_DBOX_1	219:227	Mutation altering degron motif	0.6457
p.F220S	DO233941	GACA	ICGC	SRKSLYGLE	DEG_APCC_DBOX_1	219:227	Mutation altering degron motif	0.7982
p.P211L	DO14262	HNSC	ICGC	SRKSLYGLE	DEG_APCC_DBOX_1	219:227	Mutation rewiring degron network	0.1111
p.P211L	DO14262	HNSC	ICGC	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.3056
p.P1040T	DO23376	LINC	ICGC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	1035:1042	Mutation altering degron motif	0.7031
p.V204L	DO45390	LUAD	ICGC	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.3056
p.P1040L	DO222810	MELA	ICGC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	1035:1042	Mutation altering degron motif	0.7582
p.S195N	DO232761	PBCA	ICGC	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.0556
p.G200D	DO232224	PBCA	ICGC	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.1944
p.S214L	DO37961	SKCM	ICGC	SRKSLYGLE	DEG_APCC_DBOX_1	219:227	Mutation rewiring degron network	0.1944
p.S214L	DO37961	SKCM	ICGC	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.2222
p.P208S	DO47625	SKCM	ICGC	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation altering degron motif	0.6752
p.P196L	DO219501	SKCM	ICGC	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.0833
p.A235V	DO41752	UCEC	ICGC	SRKSLYGLE	DEG_APCC_DBOX_1	219:227	Mutation rewiring degron network	0.1111
p.F207L	DO41903	UCEC	ICGC	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation altering degron motif	0.6981
p.A215D	DO41518	UCEC	ICGC	SRKSLYGLE	DEG_APCC_DBOX_1	219:227	Mutation rewiring degron network	0.2222
p.A215D	DO41518	UCEC	ICGC	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.1944
p.E209K	SIDM02039	Colorectal Carcinoma	GDSC	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation altering degron motif	0.591
p.A2529D	SIDM01137	Pancreatic Carcinoma	GDSC	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	2521:2534	Mutation altering degron motif	0.6682
p.A2529D	ACH-000235	Pancreatic Cancer	CCLE	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	2521:2534	Mutation altering degron motif	0.6682
p.A2529D	PANC-04-03	pancreas	COSMIC	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	2521:2534	Mutation altering degron motif	0.6682
p.H216Y	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	SRKSLYGLE	DEG_APCC_DBOX_1	219:227	Mutation rewiring degron network	0.25
p.H216Y	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.1667
p.H216Y	ACH-000521	Lung Cancer	CCLE	SRKSLYGLE	DEG_APCC_DBOX_1	219:227	Mutation rewiring degron network	0.25
p.H216Y	ACH-000521	Lung Cancer	CCLE	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.1667
p.H216Y	NCI-H2030	lung	COSMIC	SRKSLYGLE	DEG_APCC_DBOX_1	219:227	Mutation rewiring degron network	0.25
p.H216Y	NCI-H2030	lung	COSMIC	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.1667
p.P1046L	SIDM00189	Melanoma	GDSC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	1035:1042	Mutation rewiring degron network	0.2222
p.P1046L	ACH-002098	Skin Cancer	CCLE	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	1035:1042	Mutation rewiring degron network	0.2222
p.P1046L	CP67-MEL	skin	COSMIC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	1035:1042	Mutation rewiring degron network	0.2222
p.V1038I	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	1035:1042	Mutation altering degron motif	0.5965
p.V1038I	SIDM00200	Ewing's Sarcoma	GDSC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	1035:1042	Mutation altering degron motif	0.5965
p.V1038I	ACH-000789	Lung Cancer	CCLE	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	1035:1042	Mutation altering degron motif	0.5965
p.P1047R	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	1035:1042	Mutation rewiring degron network	0.1944
p.P1047R	SIDM00057	Neuroblastoma	GDSC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	1035:1042	Mutation rewiring degron network	0.1944
p.P1047R	SIDM01716	Non-Cancerous	GDSC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	1035:1042	Mutation rewiring degron network	0.1944
p.P1047R	SIDM00694	Other Solid Cancers	GDSC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	1035:1042	Mutation rewiring degron network	0.1944
p.P1047R	SIDM00175	Melanoma	GDSC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	1035:1042	Mutation rewiring degron network	0.1944
p.P1047R	SIDM00849	Kidney Carcinoma	GDSC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	1035:1042	Mutation rewiring degron network	0.1944
p.P1047R	SIDM01064	Hodgkin's Lymphoma	GDSC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	1035:1042	Mutation rewiring degron network	0.1944
p.P1047R	SIDM00539	Esophageal Carcinoma	GDSC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	1035:1042	Mutation rewiring degron network	0.1944
p.P1047R	SIDM00988	Kidney Carcinoma	GDSC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	1035:1042	Mutation rewiring degron network	0.1944
p.P1047R	SIDM00443	B-Cell Non-Hodgkin's Lymphoma	GDSC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	1035:1042	Mutation rewiring degron network	0.1944
p.Y224C	SIDM01259	B-Lymphoblastic Leukemia	GDSC	SRKSLYGLE	DEG_APCC_DBOX_1	219:227	Mutation altering degron motif	0.5976
p.Y224C	SIDM00381	Cervical Carcinoma	GDSC	SRKSLYGLE	DEG_APCC_DBOX_1	219:227	Mutation altering degron motif	0.5976
p.Y224C	SIDM01779	Gastric Carcinoma	GDSC	SRKSLYGLE	DEG_APCC_DBOX_1	219:227	Mutation altering degron motif	0.5976
p.Y224C	ACH-000761	Gastric Cancer	CCLE	SRKSLYGLE	DEG_APCC_DBOX_1	219:227	Mutation altering degron motif	0.5976
p.Y224C	ACH-001622	Brain Cancer	CCLE	SRKSLYGLE	DEG_APCC_DBOX_1	219:227	Mutation altering degron motif	0.5976
p.Y224C	ACH-001669	Leukemia	CCLE	SRKSLYGLE	DEG_APCC_DBOX_1	219:227	Mutation altering degron motif	0.5976
p.Y224C	ACH-002020	Cervical Cancer	CCLE	SRKSLYGLE	DEG_APCC_DBOX_1	219:227	Mutation altering degron motif	0.5976
p.Y224C	ACH-002238	Leukemia	CCLE	SRKSLYGLE	DEG_APCC_DBOX_1	219:227	Mutation altering degron motif	0.5976
p.Y224C	SKG-IIIa	cervix	COSMIC	SRKSLYGLE	DEG_APCC_DBOX_1	219:227	Mutation altering degron motif	0.5976
p.Y224C	GR-ST	haematopoietic and lymphoid tissue	COSMIC	SRKSLYGLE	DEG_APCC_DBOX_1	219:227	Mutation altering degron motif	0.5976
p.K1048E	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	1035:1042	Mutation substituting flanking lysine	0.2778
p.K1048E	ACH-001127	Leukemia	CCLE	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	1035:1042	Mutation substituting flanking lysine	0.2778
p.K1048E	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	1035:1042	Mutation substituting flanking lysine	0.2778
p.T2551A	SIDM00118	Colorectal Carcinoma	GDSC	PETTS	DEG_SPOP_SBC_1	2549:2553	Mutation altering degron motif	0.7139
p.T2551A	ACH-001081	Colon/Colorectal Cancer	CCLE	PETTS	DEG_SPOP_SBC_1	2549:2553	Mutation altering degron motif	0.7139
p.T2551A	HCC2998	large intestine	COSMIC	PETTS	DEG_SPOP_SBC_1	2549:2553	Mutation altering degron motif	0.7139
p.A2516V	SIDM01394	Kidney Carcinoma	GDSC	LAPAPLAKAPRLPI	DEG_ODPH_VHL_1	2521:2534	Mutation rewiring degron network	0.1944
p.F205L	SIDM01450	Gastric Carcinoma	GDSC	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation altering degron motif	0.587
p.F205L	ACH-000898	Gastric Cancer	CCLE	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation altering degron motif	0.587
p.V204M	ACH-000974	Endometrial/Uterine Cancer	CCLE	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.3056
p.V204M	ACH-002026	Endometrial/Uterine Cancer	CCLE	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.3056
p.V204M	SNG-M	endometrium	COSMIC	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.3056
p.A215V	ACH-000985	Colon/Colorectal Cancer	CCLE	SRKSLYGLE	DEG_APCC_DBOX_1	219:227	Mutation rewiring degron network	0.2222
p.A215V	ACH-000985	Colon/Colorectal Cancer	CCLE	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.1944
p.A215V	LS-411N	large intestine	COSMIC	SRKSLYGLE	DEG_APCC_DBOX_1	219:227	Mutation rewiring degron network	0.2222
p.A215V	LS-411N	large intestine	COSMIC	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.1944
p.R203C	ACH-001061	Colon/Colorectal Cancer	CCLE	FLPFED	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.2778
p.K1036E	ACH-001403	Ovarian Cancer	CCLE	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	1035:1042	Mutation altering degron motif	0.591
p.V1050I	EW-12	bone	COSMIC	PKDVTPPK	DEG_SCF_SKP2-CKS1_1	1035:1042	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYO15A

UniProt ID: Q9UKN7

Entrez ID: 51168

Protein name: Unconventional myosin-XV (Unconventional myosin-15)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYO15A in