DegronMD

Uniprot ID: Q9UKN7

Source protein: Unconventional myosin-XV

Source gene: MYO15A

Class: LIG_APCC_ABBA_1

Location: 205:210

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9426

ASA_SCORE: 73.0667

COIL: 0.7785

CONS_SCORE: 0.2569

DSS_SCORE: 0.3441

HELIX: 0.1257

FCONS_SCORE: 0.9966

RIG_SCORE: 0.7451

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A198T	TCGA-06-6699	GBM	TCGA	FLPFED	LIG_APCC_ABBA_1	0.1389
p.A198T	TCGA-X8-AAAR	ESCA	TCGA	FLPFED	LIG_APCC_ABBA_1	0.1389
p.A198T	DO52432	COCA	ICGC	FLPFED	LIG_APCC_ABBA_1	0.1389
p.A198T	DO13893	GBM	ICGC	FLPFED	LIG_APCC_ABBA_1	0.1389
p.D210Y	TCGA-19-4065	GBM	TCGA	FLPFED	LIG_APCC_ABBA_1	0.7325
p.D210Y	DO11591	GBM	ICGC	FLPFED	LIG_APCC_ABBA_1	0.7325
p.E211D	TCGA-CK-4951	COAD	TCGA	FLPFED	LIG_APCC_ABBA_1	0.3056
p.E211D	DO10582	COAD	ICGC	FLPFED	LIG_APCC_ABBA_1	0.3056
p.E201K	TCGA-D3-A8GQ	SKCM	TCGA	FLPFED	LIG_APCC_ABBA_1	0.2222
p.E201K	DO51246	SKCM	ICGC	FLPFED	LIG_APCC_ABBA_1	0.2222
p.E201K	ACH-001456	Colon/Colorectal Cancer	CCLE	FLPFED	LIG_APCC_ABBA_1	0.2222
p.P213S	TCGA-WE-A8K6	SKCM	TCGA	FLPFED	LIG_APCC_ABBA_1	0.25
p.P213S	DO51283	SKCM	ICGC	FLPFED	LIG_APCC_ABBA_1	0.25
p.G202A	DO223599	BLCA	ICGC	FLPFED	LIG_APCC_ABBA_1	0.25
p.A203V	DO9010	COAD	ICGC	FLPFED	LIG_APCC_ABBA_1	0.2778
p.P211L	DO14262	HNSC	ICGC	FLPFED	LIG_APCC_ABBA_1	0.3056
p.V204L	DO45390	LUAD	ICGC	FLPFED	LIG_APCC_ABBA_1	0.3056
p.S195N	DO232761	PBCA	ICGC	FLPFED	LIG_APCC_ABBA_1	0.0556
p.G200D	DO232224	PBCA	ICGC	FLPFED	LIG_APCC_ABBA_1	0.1944
p.S214L	DO37961	SKCM	ICGC	FLPFED	LIG_APCC_ABBA_1	0.2222
p.P208S	DO47625	SKCM	ICGC	FLPFED	LIG_APCC_ABBA_1	0.6752
p.P196L	DO219501	SKCM	ICGC	FLPFED	LIG_APCC_ABBA_1	0.0833
p.F207L	DO41903	UCEC	ICGC	FLPFED	LIG_APCC_ABBA_1	0.6981
p.A215D	DO41518	UCEC	ICGC	FLPFED	LIG_APCC_ABBA_1	0.1944
p.E209K	SIDM02039	Colorectal Carcinoma	GDSC	FLPFED	LIG_APCC_ABBA_1	0.591
p.H216Y	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	FLPFED	LIG_APCC_ABBA_1	0.1667
p.H216Y	ACH-000521	Lung Cancer	CCLE	FLPFED	LIG_APCC_ABBA_1	0.1667
p.H216Y	NCI-H2030	lung	COSMIC	FLPFED	LIG_APCC_ABBA_1	0.1667
p.F205L	SIDM01450	Gastric Carcinoma	GDSC	FLPFED	LIG_APCC_ABBA_1	0.587
p.F205L	ACH-000898	Gastric Cancer	CCLE	FLPFED	LIG_APCC_ABBA_1	0.587
p.V204M	ACH-000974	Endometrial/Uterine Cancer	CCLE	FLPFED	LIG_APCC_ABBA_1	0.3056
p.V204M	ACH-002026	Endometrial/Uterine Cancer	CCLE	FLPFED	LIG_APCC_ABBA_1	0.3056
p.V204M	SNG-M	endometrium	COSMIC	FLPFED	LIG_APCC_ABBA_1	0.3056
p.A215V	ACH-000985	Colon/Colorectal Cancer	CCLE	FLPFED	LIG_APCC_ABBA_1	0.1944
p.A215V	LS-411N	large_intestine	COSMIC	FLPFED	LIG_APCC_ABBA_1	0.1944
p.R203C	ACH-001061	Colon/Colorectal Cancer	CCLE	FLPFED	LIG_APCC_ABBA_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FLPFED

Degron related mutations and impact score

Drug responses associated with MYO15A mutations

All proteins holding degron of FLPFED

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKN7	Unconventional myosin-XV	LIG_APCC_ABBA_1	205:210	FLPFED	APC,CDC20,FZR1	0.9426	More...